Mitomycin C cotton pad for preventing scar adhesion and preparation method of mitomycin C cotton pad

A technology for mitomycin and cotton sheets, which is applied to cotton sheets containing mitomycin C and the field of preparation thereof, can solve the problems of easy pollution, waste of MMC drugs, complicated steps and the like, and achieves convenient use process, uniform distribution, Simple operation effect

Inactive Publication Date: 2012-05-16
JIANGSU PROVINCE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Purpose of the invention: the purpose of the present invention is to apply mitomycin C to prevent and treat the huge waste of MMC drugs in the process of cicatricial adhesions in various operations such as ophthalmology, otolaryngology head and neck surgery, plastic surgery, orthopedics, and the need for immediate preparation steps With the disadvantages of being cumbersome and easy to pollute, we provide a mitomycin cotton sheet that is easy to use and saves the dosage of MMC drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] Example: Mitomycin C cotton pads for preventing scar adhesion, using medical cotton pads as a carrier, soaking medical cotton pads in 0.4mg / ml mitomycin C solution and then vacuum drying to obtain dried mitomycin C evenly attached cotton pads. Specific production method:

[0029] Take an uncut cotton piece of 100cm×100cm as an example:

[0030] Weigh 40,000mg of mitomycin C, dissolve it in a 100L container of 100cm×100cm×20cm, mix well, completely immerse 10 pieces of 100cm×100cm cotton pieces in it, mix well, degas, soak for 5min, and place them separately Put it in a 105cm×105cm mesh, let it stand still for 5 minutes, dry it in vacuum, slice it, sterilize it, and pack it.

[0031] Concrete method of use of the product of the present invention:

[0032] Select cotton pads of appropriate specifications and place them in the corresponding anti-scar adhesion area. Selectively use appropriate amount of saline according to the amount of tissue fluid and blood in the cor...

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PUM

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Abstract

The invention discloses a mitomycin C cotton pad for preventing scar adhesion. With a medical cotton pad as a carrier, the medical cotton pad is immersed in a mitomycin C solution and then dried in vacuum to obtain a dried cotton pad on which mitomycin C is uniformly attached. The invention also discloses a preparation method and a use method of the mitomycin C cotton pad. According to the mitomycin C cotton pad disclosed by the invention, the processes of preparing the mitomycin C solution and shearing the cotton pad to reach a proper size in operation are avoided, operation time is saved, operation is enabled to be convenient and rapid, and risks of operation pollution are reduced.

Description

technical field [0001] The invention relates to a cotton sheet containing mitomycin C and a preparation method thereof. Background technique [0002] Mitomycin C (MMC) is a natural antibiotic isolated from the culture medium of actinomycetes Streptomyces caespitosus by Japanese microbiologists in 1956. It is a component of ethyleneimine antibiotics (C 15 h 18 N 4 o 5 ), which is activated in tissues to become an alkylate, which has alkylation effect, forms a cross-link with the double helix of A molecule, destroys the structure and function of DNA, inhibits DNA replication in the proliferative phase and can inhibit RNA-dependent DNA synthesis , so as to effectively inhibit the proliferation of fibroblasts and prevent fibroblasts from producing collagen: MMC is a relatively non-specific drug for cell cycle, which affects the entire cell cycle activity and has effects on cells in all stages of proliferation and quiescent cells. Experimental studies have proved that MMC has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44
Inventor 曹晓建谢浩眭涛宗祥峰魏继福
Owner JIANGSU PROVINCE HOSPITAL
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