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Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol

A technology of chronic renal failure and aerosol, which is applied in the direction of aerosol delivery, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of no ratio relationship, affecting drug efficacy, and high usage of astragalus

Active Publication Date: 2012-05-30
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but Astragalus is used in a high amount, and astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza may also react. If the dosage of astragalus is small in the compatibility of the preparation, it will affect the efficacy of the medicine. The ratio of traditional Chinese medicine directly affects the curative effect of the preparation. Minimal side effects are crucial

Method used

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  • Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol
  • Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol
  • Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol

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Effect test

Embodiment 1

[0091] The Shenkang aerosol for external use is characterized in that it is made of the following raw materials: rhubarb 1500g, salvia miltiorrhiza 1500g, astragalus 4500g and safflower 1500g.

[0092] The preparation method of Shenkang topical aerosol, after extracting the raw materials rhubarb and salvia miltiorrhiza according to the proportion of the above formula, first alcohol precipitation, detanning, second alcohol precipitation, water precipitation, third alcohol precipitation, and second water precipitation ; and then extract astragalus and safflower according to the proportion of the above formula, once again alcohol precipitation, water precipitation, second alcohol precipitation, water precipitation, ultrafiltration and concentration to make an aerosol.

Embodiment 2

[0094] The preparation method of Shenkang external aerosol is as follows: take rhubarb and salvia miltiorrhiza, add 7-12 times the amount of the original medicinal materials for the first time, soak for 30 minutes, boil for 30 minutes, filter, and add water for the second time 7-12 times the original medicinal materials. -12 times the amount, boil for 30 minutes, filter, add water for the third time to 7-12 times the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.18 to 1.25 at 60°C, add 95% ethanol, until the alcohol content of the medicinal solution is 70%, let it stand for 38-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.18-1.25 at 60°C, add 5% gelatin solution, remove tanning, Add 95% ethanol until the alcohol content is 75%, let it stand for 38-60 hours, take the supernatant, filter and clarify, recover the ethanol until the relative densit...

Embodiment 3

[0096] The preparation method of Shenkang aerosol for external use is as follows: take rhubarb and salvia miltiorrhiza, add 10 times the amount of the original medicinal materials for the first time, soak for 30 minutes, boil for 30 minutes, filter, and add water for the second time 8 times the amount of the original medicinal materials , boil for 30 minutes, filter, add water for the third time to 7 times the amount of the original medicinal material, boil for 30 minutes, filter, combine three water extracts, concentrate to a relative density of 1.20-1.22 at 60 ° C, add 95% ethanol, until the drug The alcohol content of the solution is 70%, let stand for 48-60h, take the supernatant and filter until clear, recover the ethanol until the relative density is 1.20-1.22 at 60°C, add 5% gelatin solution, remove tanning, add 95% ethanol, until The alcohol content is 75%, stand still for 48-60h, take the supernatant, filter and clarify, recover the ethanol until the relative density i...

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Abstract

The invention relates to a Shenkang aerosol for treating chronic renal failure and a preparation method of the Shenkang aerosol. The Shenkang aerosol for treating chronic renal failure is prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation; and then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, carrying out secondary ethanol precipitation and water precipitation, and preparing into the soft capsule after the mixture is condensed into the aerosol. The Shenkang aerosol for treating chronic renal failure has the advantages of precision in regulating the original ratio, small side effect, good stability, definite curative effect and convenience in use.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine aerosol and a preparation method thereof, in particular to a Shenkang aerosol for treating chronic renal failure and a preparation method thereof. Background technique [0002] The original patent 200410039418.X discloses a kind of Shenkang suppository and its preparation method. Its prescription protects the scope of use of traditional Chinese medicine, and there is no specific ratio relationship. Although the case of the prescription is also disclosed in the patent document embodiment, but Astragalus is used in a high amount, and astragalus and rhubarb have a precipitation reaction, astragalus and salvia miltiorrhiza may also react. If the dosage of astragalus is small in the compatibility of the preparation, it will affect the efficacy of the medicine. The ratio of traditional Chinese medicine directly affects the curative effect of the preparation. Minimal side effects are crucial. Contents ...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/12A61P13/12
Inventor 曹凤君吕延英詹芳赵兴王光建王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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