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Micro-needle transdermal delivery patch with high penetration efficiency

A micro-needle sticker, high-penetration technology, applied in the directions of micro-needle, needle, sheet delivery, etc., can solve the problems of limited drug loading, complicated process, limited hardness and strength, etc., to shorten the treatment period and expand the treatment range. , improve the effect of treatment

Active Publication Date: 2012-09-12
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this dissolvable microneedle also has disadvantages: 1) the drug load is limited, and if it exceeds a certain limit, the polymer cannot be constructed into a microneedle material; 2) due to the microneedle of the polymer, its hardness, strength Limited, the skin penetration efficiency is not high, and the drug cannot be used universally; 3) Due to the blending of the drug and the polymer, the process is complicated, and the drug is subject to certain restrictions, not all drugs can be blended with the polymer construction of microneedles
The activity of the constructed drug will be affected to a certain extent, especially for biological and genetic drugs, there is a possibility of losing activity and drug efficacy

Method used

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  • Micro-needle transdermal delivery patch with high penetration efficiency
  • Micro-needle transdermal delivery patch with high penetration efficiency
  • Micro-needle transdermal delivery patch with high penetration efficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Self-permeable microneedle transdermal input patch product

[0033] The overall microneedle patch is constructed by downloading medicine, such as figure 1 shown. Firstly, a layer of dodecyl mercaptan 102 is modified on the surface of the microneedle 103 (taking a metal microneedle as an example) by means of liquid phase self-assembly. These alkyl groups function to enhance the biocompatibility of the microneedle surface. The medicine 104 is loaded, and the Yunnan Baiyao medicine liquid is adsorbed on the absorbent cotton to form cotton wool. It is then quickly encapsulated with a polymer material 105 of polydimethylsiloxane. Form a sac. The drug capsule and the microneedle are combined by bioglue to form a microneedle drug carrier with an inseparable integrated structure. In order to reduce volatilization, compound the surface modification material of 101. Encapsulation can be done with cotton wool coated with a thin layer of organic layer. The organ...

Embodiment 2

[0034] Embodiment 2 microneedle transdermal input patch product with propellant

[0035] The overall microneedle patch is constructed by means of internal drug loading, such as figure 2 shown. On the 103 microneedle modified with the 102 compatible material layer, the microneedle is placed in the drug solution for drug adsorption. If necessary, a certain negative pressure can be added to the system to increase the drug adsorption speed . After a certain period of time, the internal pores of the microneedle array will absorb a certain amount of 104 drugs (taking collagen as an example). Immediately carry out the cotton wool 101 encapsulating the thin layer of organic matter. On the rear side of the microneedle, the upper layer in the figure is used as the temperature-sensitive material of the drug-driven structure 108 for packaging 105, and high-density polyethylene material can be used. After assembly, 106 and 107 are packaged to form a patch product. During implementati...

Embodiment 3

[0036] Example 3 The microneedle transdermal input patch product that can replace the medicine capsule

[0037] The overall microneedle patch is constructed by downloading medicine, such as figure 1 shown. The main construction method is the same as in Example 1. After putting in the cotton wool 104, we do not use the inseparable combination method, but use a detachable combined structure to construct the patch, and use a special adhesive tape to compound 105. When the drug in the cotton wool is used up, we can tear off the 105 and 106 parts from the patch, take out the 104 cotton wool, put in a new cotton wool, (it can be the same or different from the original cotton wool) and paste 105 back to the patch. The main part becomes a new patch. In the patch, the drug can be added repeatedly, which is especially suitable for the use of large doses of drugs, effectively reduces the cost, and expands the application of the patch. If the types of drugs added each time are differen...

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Abstract

The invention relates to a micro-needle transdermal delivery patch with high penetration efficiency, and belongs to a medicament and equipment integrated patch product. The micro-needle transdermal delivery patch can painlessly and efficiently deliver medicament waiting delivery matters to the subcutaneous part, and achieves treatment, beautifying and health-care effects. In addition, under the stimulation of external force, heat, light, electricity, magnetic field, electric field and the like, the penetration effect can be accelerated, so that the micro-needle delivery patch has a curative effect which is not achieved in a common medicinal patch, the application range of the medicinal patch is expanded, and the curative effect of medicaments are improved. The invention relates to the structural design of the novel micro-needle transdermal delivery patch and the core technology of the implementation process, and the patch can be used for treating skin and shallow skin diseases and can also be used for treatment and related nursing operation of deep tissues and endocrine system diseases. The micro-needle delivery patch product conforms to the tide of future medical treatment, really realizes the advanced treatment concepts of painless delivery and happy treatment, is a novel patch product, and particularly has a broad market prospect for special crowds such as old people and children.

Description

Technical field: [0001] This patent relates to the field of medical equipment and medicine, specifically to the fields of highly permeable patches and band-aids. technical background [0002] As a commonly used medical product, patch is popular among patients because of its convenient operation and wide range of diseases. Many medicines are in the form of patches, such as Pain Relief Patch and Detumescence Patch. However, due to the low penetration efficiency of traditional patch products, the treatment cycle is very long, and the treatment effect is slow, and the usual course of treatment is several days to several weeks. In addition, due to the limitation of penetration efficiency, it is usually difficult to achieve the minimum drug dose required for the treatment of some diseases, which limits the application range of the patch and makes it impossible to use the patch preparation to achieve the purpose of treatment for many diseases. [0003] From the perspective of the...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/70
CPCA61K9/0009A61K9/0021A61M37/0015A61M2037/0061
Inventor 张晓安杨秉杰吴宝山刘觉唤朱楠嵩
Owner JILIN UNIV
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