Compositions And Methods Modulating Mg29 For The Treatment Of Diabetes

A technology of MG29 and drugs, which is applied in the field of regulating muscle function and treating diseases, and can solve problems such as inability to store properly
CN102481337AActive Publication Date: 2012-05-30RUTGERS THE STATE UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RUTGERS THE STATE UNIV
Publication Date
2012-05-30

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Abstract

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and / or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal musle disorders. Moreover, the invention relates to the treatment and / or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.
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Description

[0001] References to related applications

[0002] This application claims the benefits of U.S. Provisional Patent Application No. 61 / 217,926, filed June 5, 2009, entitled "Compositions and Methods Modulating MG29 for the Treatment of Diabetes" Priority benefit, this Provisional Patent Application is hereby incorporated by reference for all purposes.

[0003] Statement Regarding Federally Funded Research

[0004] The US Government has certain rights in this invention pursuant to the following grant: RO1-AG15556 awarded by the National Institutes of Health (NIH) to Dr. Jianjie Ma. technical field

[0005] The present invention relates to recombinant nucleic acid and polypeptide compositions and methods of using them to modulate muscle function and treat disease.

[0006] Incorporation of References

[0007] A sequence listing in computer readable form is submitted with this application: file name: MG29v2_seqlist_ST25.txt, size 68KB, created on June 3, 2010, generated using P...

Claims

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