Compositions And Methods Modulating Mg29 For The Treatment Of Diabetes

A technology of MG29 and drugs, which is applied in the field of regulating muscle function and treating diseases, and can solve problems such as inability to store properly

Active Publication Date: 2012-05-30
RUTGERS THE STATE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] If the amount of insulin available is insufficient, if cells do not respond well to insulin (insulin insensitivity or insulin resistance), or if insulin itself is defective, then glucose will not be able to do its usual job and cannot be used by the cells of the body that need it Properly absorbed and not properly stored in the liver and muscles

Method used

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  • Compositions And Methods Modulating Mg29 For The Treatment Of Diabetes
  • Compositions And Methods Modulating Mg29 For The Treatment Of Diabetes
  • Compositions And Methods Modulating Mg29 For The Treatment Of Diabetes

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preparation example Construction

[0183] The preparation of monoclonal antibodies is well known in the art, see, for example, Harlow et al., Antibodies: A Laboratory Manual, page 726 (Cold Spring Harbor Pub. 1988), USPNs: 6331415 to Cabilly; 6407213 and 6639055 to Carter; 6562622; 6693176; 6881557; 5807715 of Morrison; 5225539 of Winter; 5585089, 5693761, 6180370 and 7022500 of Queen; 20070202105 of Doyle, all of which are incorporated herein by reference. Monoclonal antibodies can be obtained by injecting a composition containing an antigen into a mouse or rabbit, confirming the presence of the antibody by taking a serum sample, removing the spleen to obtain lymphocytes, and fusing the lymphocytes with myeloma cells to produce hybridization tumors, hybridomas are cloned, positive clones producing antibodies to the antigen are selected, and the antibodies are isolated from hybridoma cultures. Monoclonal antibodies can be isolated and purified from hybridoma cultures by techniques well known in the art.

[018...

Embodiment

[0243] Embodiment (with reference to accompanying drawing)

[0244] Mitsugumin 29 (MG29): A protein related to muscle-specific synaptophysin was isolated. The skeletal muscle triad is composed of a single depressed portion of the plasma membrane (transverse or T-tubules) trapped in the cytoplasm that is juxtaposed with two portions of the terminal pool of the sarcoplasmic reticulum (SR). Given the importance of the triplet in inducing muscle contraction, an antibody library was screened by immunostaining for novel proteins localized in the triplet, identifying regulators of excitation-contraction (E-C) coupling and Ca in skeletal muscle 2+ Other proteins that regulate other aspects are not surprising. One of the most important proteins identified during the screening of this library was a new member of the synaptophysin family of transmembrane proteins, mitsugumin 29 (MG29).

[0245] MG29 is almost exclusively expressed in mouse and human skeletal muscle fibers, but little e...

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Abstract

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal musle disorders. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

Description

[0001] References to related applications [0002] This application claims the benefits of U.S. Provisional Patent Application No. 61 / 217,926, filed June 5, 2009, entitled "Compositions and Methods Modulating MG29 for the Treatment of Diabetes" Priority benefit, this Provisional Patent Application is hereby incorporated by reference for all purposes. [0003] Statement Regarding Federally Funded Research [0004] The US Government has certain rights in this invention pursuant to the following grant: RO1-AG15556 awarded by the National Institutes of Health (NIH) to Dr. Jianjie Ma. technical field [0005] The present invention relates to recombinant nucleic acid and polypeptide compositions and methods of using them to modulate muscle function and treat disease. [0006] Incorporation of References [0007] A sequence listing in computer readable form is submitted with this application: file name: MG29v2_seqlist_ST25.txt, size 68KB, created on June 3, 2010, generated using P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K38/17A61K31/7105A61P3/10A61P3/00
CPCA61K38/1709A61K31/7105C07K14/705A61P3/00A61P3/10A61K38/16A61K38/17
Inventor 林培惠麻建杰诺厄·魏斯勒德朱骅
Owner RUTGERS THE STATE UNIV
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