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Biological disinfectant

A biological disinfectant, polylysine technology, applied in the direction of disinfectants, biocides, biocides, etc., can solve the problems of skin or equipment corrosion, irritation and so on

Inactive Publication Date: 2012-06-20
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using chemical disinfectants, the dose should be strictly controlled. When the concentration is high, most of them are irritating and will cause corrosion to the skin or equipment, which brings great inconvenience to actual use.

Method used

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  • Biological disinfectant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The biological disinfectant contains the following components: ε-polylysine 5 mg / mL, glycine 5 mg / mL, dodecyl dimethyl betaine (BS-12) 8 mg / mL, glycerin 2 mg / mL, The balance is a buffer solution with a pH value of 7.0.

[0011] The preparation method is as follows:

[0012] Weigh 556 mg of ε-polylysine (purity>90%), 500 mg of glycine, 800 mg of 30% dodecyl dimethyl betaine (BS-12), and 200 mg of glycerol, and add them to the 0.2 M disodium hydrogen phosphate and 0.1 M citric acid (pH = 7.0) buffer to make a total volume of 100 mL.

Embodiment 2

[0014] The biological disinfectant contains the following components: ε-polylysine 0.5 mg / mL, lauryl dimethyl betaine (BS-12) 2 mg / mL, cocamidopropyl betaine (CA-35 ) 10 mg / mL, glycerol 1 mg / mL, and the balance as a buffer solution with a pH value of 7.0.

[0015] The preparation method is as follows:

[0016] Weigh ε-polylysine (purity>90%) 56 mg, 30% lauryl dimethyl betaine (BS-12) 200 mg, 30% cocamidopropyl betaine (CA- 35) 1000 mg and 100 mg of glycerol were added to the buffer containing 0.2 M disodium hydrogen phosphate and 0.1 M citric acid (pH value = 6.8) in order to make the total volume 100 mL.

Embodiment 3

[0018] The biological disinfectant contains the following components: ε-polylysine 2 mg / mL, lauryl dimethyl betaine (BS-12) 16 mg / mL, glycerin 4 mg / mL, and the balance is pH 7.2 buffer solution.

[0019] The preparation method is as follows:

[0020] Weigh 222 mg of ε-polylysine (purity>90%), 1600 mg of 30% dodecyl dimethyl betaine (BS-12), 400 mg of glycerol, and add them in turn to the solution containing 0.2 M phosphoric acid Sodium hydrogen disodium and 0.1 M citric acid (pH = 7.2) buffer to make a total volume of 100 mL.

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Abstract

The invention discloses a biological disinfectant with safety, high efficiency and low irritation. One milliliter of the biological disinfectant comprises the following components: 0.5 to 10 milligrams of epsilon-polylysine, 1 to 20 milligrams of glycerol, 0.8 to 16 milligrams of dodecyl dimethyl betaine and the balance of buffer solution with the pH value of 6.0 t 7.5. The biological disinfectant can be used for disinfecting hand skin, the surfaces of objects and the like. The sterilizing log value of the biological disinfectant on Escherichia coli and candida albicans within 3 minutes is more than 3. The sterilizing log value of the biological disinfectant on pseudomonas aeruginosa and staphylococcus aureus is more than 6. As the contact lasts, a disinfecting effect becomes better.

Description

technical field [0001] The invention relates to the field of disinfection preparation and its application technology, in particular, it provides a biological disinfection preparation containing ε-polylysine. Background technique [0002] At present, the types of disinfectants on the market are mainly chemical disinfectants, and the active ingredients of almost all disinfectants are concentrated in the following types: chlorhexidine acetate, iodine, povidone, chlorhexidine, benzalkonium chloride, polyhexachloride Methylene guanidine, dialkyl quaternary ammonium salt and chlorhexidine acetate mixture, single and double chain quaternary ammonium salt, compound disinfectant prepared with multiple alcohols (ethanol, isopropanol, ethylene glycol, butylene glycol and Polymer alcohols with polar groups, etc., with a total alcohol content of 55%), compound disinfectant (650 mg / L low-concentration polyhexamethylene biguanide hydrochloride and didecyldimethylammonium chloride, benzalko...

Claims

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Application Information

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IPC IPC(8): A01N37/46A01N37/44A01P1/00A01P3/00A61K31/785A61K31/205A61P31/04A61P31/10
CPCY02A50/30
Inventor 郝丽梅祁建城
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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