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Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania

A technology for extracts and depression, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2012-07-04
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacological studies have shown that Danshen can improve the ischemia-reperfusion injury of the heart, liver, and lung, regulate immune responses, and exert anti-inflammatory and anti-infective effects. However, there is no research report on the use of Danshen extract in the treatment of depression.

Method used

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  • Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania
  • Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania
  • Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1 Antidepressant Effect of Salvia Miltiorrhiza Extract in Mice Forced Swimming Test

[0008] experimental method:

[0009] The forced swimming test was first established by Porsolt. Its basic principle is that when a mouse swims in a narrow and unavoidable container, after the initial struggle, the body will float in the water or slide back slightly to maintain a Immobility behavior, also known as hopelessness behavior, was reduced when the animals received antidepressant drugs before the experiment.

[0010] In the experiment, 40 mice were divided into normal saline group, low (5mg / kg), medium (10mg / kg), high dose (20mg / kg) Danshen extract group and imipramine (20mg / kg) group five Experimental groups with 8 animals in each group. Intraperitoneally administered 24 hours, 1 hour and 0.5 hours before the experiment, and then placed the mice in a glass cup with a water depth of 12 cm and a water temperature of 22±1°C and a size of 21×12 cm. Swimming was maintain...

Embodiment 2

[0016] Example 2 The antidepressant effect of Salvia miltiorrhiza extract in mouse tail suspension experiment

[0017] experimental method:

[0018] The tail-suspension test is a rapid, high-throughput screening method for the acute behavioral effects of antidepressants. The main basis is that when a normal animal is in a short-term unavoidable adversity (such as hanging its tail at a certain height from the ground), its behavior will switch from a moving state to an immobile state, and giving antidepressant drugs before the experiment will not The time of immobility in this can be reduced.

[0019] In the laboratory, 40 mice were divided into normal saline group, low (5mg / kg), medium (10mg / kg), high dose (20mg / kg) Danshen extract group and imipramine (20mg / kg) group Five experimental groups with 8 animals in each group. Intraperitoneally administered 24 hours, 1 hour and 0.5 hours before the experiment, and then the tip of the tail of the mouse was fixed at a height of 60 ...

Embodiment 3

[0025] The influence of embodiment 3 Salvia miltiorrhiza extract on spontaneous activity measurement in mice

[0026] experimental method:

[0027] The spontaneous activity of the mice was tested by Taimeng ZZ-6 Mouse Autonomous Activity Tester. In the laboratory, 40 mice were divided into normal saline group, low (5mg / kg), medium (10mg / kg), high Dosage (20mg / kg) Danshen extract group and imipramine (20mg / kg) group five experimental groups, 8 animals in each group. The mice were administered intraperitoneally 24 hours, 1 hour and 0.5 hours before the experiment respectively, and the mice were placed in the measurement chamber of the tester to adapt for 5 minutes, and then the number of activities and the number of standing of the mice in 10 minutes were recorded.

[0028] Experimental results:

[0029] Table 3 The effect of Danshen extract on the number of activities in mice

[0030]

[0031] Note: Compared with the normal group, *p<0.05, **p<0.01

[0032] Table 4 The e...

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Abstract

The invention relates to the technical field of medicine, in particular to a novel application of a red-rooted salvia root extract. As proved by an animal experiment, the red-rooted salvia root extract has the effect of treating tristimania, and is a natural anti-tristimania agent with a good development prospect, so that the red-rooted salvia root extract can be used for preparing a medicament for treating tristimania.

Description

technical field [0001] The invention relates to the technical field of medicine, is a new application of salvia miltiorrhiza extract in preparing medicine for treating depression, and belongs to the field of natural medicine development. Background technique [0002] Mood disorder is a medical term describing an abnormal state of mind. It is short-term depression when faced with certain regrets or due to some disappointment. It is a common phenomenon in daily life. When affected, it is called depression. Depression is a very common disease. About 10-15% of the population will have different degrees of depression in certain periods of their lives, and patients with depression often have serious suicidal tendencies. According to surveys, more than 30,000 people in the United States each year Suicide, while depression is thought to be a major factor. [0003] The drugs currently used to treat depression are all designed to target the monoamine system, mainly tricyclic antidep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P25/24
Inventor 丰毅游自立鄢硕
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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