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Application of dencichine in preparation of medicament for treating neurodegenerative diseases

A technology of neurodegenerative diseases and panax notoginseng, which is applied in the field of medicine, can solve the problems of insignificant neurotoxicity and neurotoxicity of panax notoginseng

Inactive Publication Date: 2012-07-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, many studies have found that Panax notoginseng has neurotoxic effects
It has been reported in the literature that the neurotoxicity reaction is not obvious at 50 mg / kg (effective therapeutic dose) of rats injected intravenously with Panax notoginseng, but high doses (8-12 times the effective therapeutic dose) may cause neurotoxicity

Method used

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  • Application of dencichine in preparation of medicament for treating neurodegenerative diseases
  • Application of dencichine in preparation of medicament for treating neurodegenerative diseases
  • Application of dencichine in preparation of medicament for treating neurodegenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] cell experiment

[0011] 1 Materials and methods

[0012] 1.1 Cell culture and grouping

[0013] In this experiment, the nerve cell line PC12 cells (provided by Xijing Hospital of Fourth Military Medical University) were used, cultured in DMEM medium containing 10% fetal bovine serum by volume fraction, cultured at 37°C and 5% CO, passaged at 1:4, and selected Experiments were performed on cells in logarithmic growth phase.

[0014] Morphological observation

[0015] cells by 5 x 10 4 Seed in a 24-well plate at a density of / well, add different concentrations of notoginseng to each well after culturing for 48 hours, and take pictures under a microscope after culturing for another 48 hours to observe the changes in cell morphology.

[0016] Establishment of chronic hypoxia model

[0017] The experiment was divided into three groups, which were the normal control group, the chronic hypoxia group, and the chronic hypoxia notoginseng intervention group (the concentr...

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Abstract

The invention relates to application of a dencichine medicament, in particular to the application of a small dose of dencichine in preparation of a medicament for treating chronic neurologic diseases. A cytological method is used by researchers of the experiment, so that the condition that a small dose of dencichine can achieve a protection effect on neurogenic cell damages caused by a chronic anoxic effect is proved and a protection effect of a small dose of dencichine on the chronic neurologic diseases is prompted by a cellular morphology observation method, a cellular staining method and other methods by establishing a cellular chronic anoxic model and the like.

Description

technical field [0001] The invention relates to a new application of notoginseng, in particular to the application of notoginseng in the preparation of medicines for treating neurodegenerative diseases, and belongs to the field of medicine. Background technique [0002] Neurodegenerative diseases refer to degenerative diseases of the nervous system caused by neuron degeneration and apoptosis. Histopathological studies have shown that neurons undergo slow and progressive apoptosis, and most of them have abnormal protein aggregation and inclusion bodies in neurons, suggesting that they may have similar pathogenesis, such as abnormal mitochondrial function due to genetic mutations, free radical production, excitatory Sexual toxicity, abnormal protein post-transcriptional modification, neurotrophic factor deficiency, etc., but the specific etiology is unknown. The clinical manifestations are mainly divided into two types: motor dysfunction and memory and cognitive dysfunction. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P25/28
Inventor 赵钢
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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