Medical disinfecting ultrasound gel composition and preparation method

A gel composition, ultrasonic technology, applied in echo/ultrasonic imaging agent, emulsion delivery, aerosol delivery and other directions, can solve the problems of unavoidable cross infection, easy rupture of condoms, etc., and achieve the effect of avoiding cross infection

Active Publication Date: 2012-07-18
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to avoid cross-infection in ultrasonic testing, the probe is often coated with ultrasonic gel and then covered with a transp

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] This example will illustrate an example of preparing 1000 g of the medical disinfectant ultrasonic gel composition of the present invention.

[0014] Product formula: 5 g carbomer, 0.5 g chitosan, 10 g glycerin, 3 g o-phthalaldehyde, 2 g m-phthalaldehyde, 1 g terephthalaldehyde, 1.0 g disodium EDTA, appropriate amount of NaOH, and the balance is deionized water.

[0015] Among them, carbomer-934 as a water-soluble polymer material accounts for 0.5% (i.e. 5g) of the total mass of the raw material reagent; chitosan as a bactericidal synergist component accounts for 0.05% (i.e. 0.5g) of the total mass of the raw material reagent ); Glycerin as an emollient and moisturizing component accounts for 1% (i.e. 10g) of the total mass of the raw material reagent; as a sterilizing component, o-phthalaldehyde, m-phthalaldehyde, and terephthalaldehyde mixture account for 1% of the total mass of the raw material reagent 0.6% (ie 6g); disodium EDTA as a stable component accounts for 0...

Embodiment 2

[0023] Product formula: carbomer 6 g, taurine 1 g, propylene glycol 20 g, o-phthalaldehyde 5 g, EDTA 0.5 g, appropriate amount of KOH, and the balance is deionized water.

[0024] Preparation method: Disperse carbomer in 94g deionized water, stir at 25°C (60-150 rpm) to disperse evenly, then change to slow stirring (60-120 rpm), add taurine respectively , propylene glycol, o-phthalaldehyde, more EDTA, make up the remaining amount of deionized water, add an appropriate amount of NaOH solution to adjust the viscosity, control the pH to 5.5-7.5, vacuum degassing for 5 minutes, and pack in a can.

Embodiment 3

[0026] Product formula: 8 g of carbomer, 1 g of chitosan, 30 g of glycerin, 6 g of isophthalaldehyde, 1 g of terephthalaldehyde, 2 g of disodium EDTA, an appropriate amount of citric acid, and the balance is deionized water.

[0027] Preparation method: Disperse carbomer in 90g deionized water, stir rapidly at 25°C to disperse evenly, then change to slow stirring, add chitosan, glycerin, isophthalaldehyde and terephthalaldehyde, disodium EDTA , make up the remaining amount of deionized water, add an appropriate amount of citric acid solution to adjust the viscosity, control the pH to 5.5-7.5, vacuum degassing for 10 minutes, and pack in cans.

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Abstract

The invention discloses a medical disinfecting ultrasound gel composition and a preparation method. The Medical disinfected ultrasound gel composition comprises, by mass, 0.1-3% of aldehydes bactericide, 0.3-3% of water-soluble polymer, 0.05-1% of disinfection synergist, 0.05-1% of stabilizing agent, 1-5% of skin moisturizing humectant, a potential of hydrogen (pH) regulating and controlling component and the balance deionized water. Ultrasound gel is not required to be specially disinfected after ultrasonic inspection, can directly kill microorganism on an ultrasonic probe and effectively avoids cross-infection caused by probe contact. The medical disinfecting ultrasound gel composition has low contacting irritation to intact skin, orifices, mucosa, wound and the like, and is non-toxic and free of side effect.

Description

technical field [0001] [0002] The invention relates to a medical disinfectant ultrasonic gel composition used in ultrasonic detection and a preparation method thereof. technical background [0003] Medical ultrasound gel is used for clinical ultrasound diagnosis. The basic requirements are that it can effectively transmit sound waves, with small sound wave attenuation, clear images, no damage to the probe, and non-toxic and non-irritating to the human body. Since the ultrasonic probe is frequently in contact with different patient detection sites, cross-infection is likely to occur, especially for ultrasonic detection of cavities, mucous membranes, incomplete skin, and acupuncture. In order to avoid cross-infection in ultrasonic testing, it is often used to apply ultrasonic gel on the probe and then cover the probe with a transparent condom for testing. However, since the condom is easy to break during the ultrasonic process, cross-infection cannot be avoided. At present...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K9/06
Inventor 杜志云薛贵华黎永良王婷关书杰张焜郑希苏博云贾乾发汪舰曾华强艾伦·康尼
Owner GUANGDONG UNIV OF TECH
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