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New application of peiminine in manufacturing gastric cancer multidrug resistance reversing medicaments

A multi-drug resistance and peiminin B technology, which is applied in drug combinations, antineoplastic drugs, and pharmaceutical formulations, can solve problems such as too small doses, improper drug selection, and high toxicity, and achieve IC50 value reduction , reduced drug resistance, enhanced toxicity

Active Publication Date: 2012-07-25
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mid-to-late 1980s was a period of active research and development of anti-tumor microbial drugs. However, due to their high toxicity, although monoclonal antibody-coupled targeted drug delivery can be used to reduce toxic and side effects, it is still not possible. Meeting Human Needs for More Perfect Medicines
(2) Improper choice of drug, too small dose, and insufficient duration
(3) The general condition of the patient is poor
(5) The patient discontinued chemotherapy without authorization due to overreaction, so that the chemotherapy drug did not reach the effective dose

Method used

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  • New application of peiminine in manufacturing gastric cancer multidrug resistance reversing medicaments
  • New application of peiminine in manufacturing gastric cancer multidrug resistance reversing medicaments
  • New application of peiminine in manufacturing gastric cancer multidrug resistance reversing medicaments

Examples

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Effect test

Embodiment 1

[0026] Example 1, the new application of the peiminin B in the preparation of drugs for reversing the multidrug resistance of gastric cancer, the molecular formula of the peiminin B is C 27 H 43 NO 3 , Molecular weight is 429.63522, its structural formula is as follows:

[0027]

[0028] The new medical application of the peiminin: 20ug / ml peiminin can reverse the multidrug resistance of gastric cancer cells, and significantly improve the sensitivity of drug-resistant cells to commonly used chemotherapeutics. Peiminin B has an inhibitory effect on gastric cancer parental cells and drug-resistant cells, and the relevant experimental data are as follows:

[0029] (1) Toxicity determination of peiminin B on SGC7901 and SGC7901 / VCR cells

[0030] The inhibitory effect of peiminin B on the growth of parental cell SGC7901 and drug-resistant cell SGC7901 / VCR was detected by MTT colorimetry. As the concentration of peiminin B increased, the viability of the t...

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Abstract

The invention relates to new application of peiminine in manufacturing gastric cancer multidrug resistance reversing medicaments. The molecular formula and the molecular weight of peiminie are respectively C27H43NO3 and 429.63522. The beneficial effects provided by the invention are as follows: peiminine is used as a reserving agent; and cytotoxicity tests show that peiminine can obviously increase the sensitivity of drug resistance cells SGC7901 / VCR on chemotherapeutics when being used together with commonly applied chemotherapeutics such as VCR (vincristine), ADR (adriamycin), CDDP (cis-platinum) and 5-Fu (5-fluorouracil). The result points out that when peiminie is applied with the chemotherapeutics to inhibit proliferation of the drug resistance cells, the proliferation capacity and the drug resistance level of the drug resistance cells are reduced, IC50 (half inhibitory concentration ) of the chemotherapeutics is reduced, and the cytotoxicity is increased. Therefore, peiminine can not only inhibit the proliferation of gastric cancer cells but also has the function of reserving gastric cancer multidrug resistance.

Description

technical field [0001] The invention belongs to the technical field of preparing a medicine for reversing multidrug resistance of gastric cancer with peiminin B, and relates to a new application of peiminin B for preparing a medicine for reversing multidrug resistance of gastric cancer. Background technique [0002] Current medical market demand for anticancer drugs and drug treatment effects [0003] With the acceleration of social urbanization and industrialization, environmental pollutants and new chemical substances are increasing day by day, coupled with bad lifestyle and behavior habits, such as irregular life, mental stress, anxiety, improper diet, smoking and drinking, bad temper, exercise Tumors have become one of the major diseases that endanger human life and health. Malignant tumors not only seriously threaten human life and health, but also cause heavy burdens to families, society, and the country, and interfere with economic construction and social development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P35/00A61P1/00
Inventor 顾政一张裴孙玉华黄华
Owner XINJIANG INST OF MATERIA MEDICA
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