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Application of canosic acid in preparing medicines used for preventing or treating diseases relating to liver injury

A technology of carnosic acid and liver damage, which is applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., to achieve the effects of inhibiting the increase of immune factors, reducing the increase of transaminases, and improving liver pathological damage

Inactive Publication Date: 2012-08-01
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been reports that carnosic acid can inhibit the production of superoxide ions, and inhibit the peroxidation of microsomal and mitochondrial lipids, and has various pharmacological activities, such as anti-inflammatory, anti-tumor, and treatment of cardiovascular diseases. However, there are no relevant reports on the application of carnosic acid in liver protection

Method used

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  • Application of canosic acid in preparing medicines used for preventing or treating diseases relating to liver injury
  • Application of canosic acid in preparing medicines used for preventing or treating diseases relating to liver injury
  • Application of canosic acid in preparing medicines used for preventing or treating diseases relating to liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 carnosic acid oil solution

[0016] Weigh 6.0 g of carnosic acid and pass through a 100-mesh sieve, add it to 1000 ml of olive oil, stir until the carnosic acid is completely dissolved to obtain a clear oil solution, and pack it separately to obtain the product.

Embodiment 2

[0017] Embodiment 2 Preparation of rosemary fat-soluble extract oil solution

[0018] Weigh 10.0g of rosemary fat-soluble extract (containing carnosic acid 65% W / W) and pass through a 100-mesh sieve, add 1000ml of olive oil, stir at room temperature until the rosemary fat-soluble extract is completely dissolved to obtain a clear oil solution, and pack , that is.

Embodiment 3

[0019] Example 3 Preparation of Carnosic Acid Capsules

[0020] Weigh 90.0g of rosemary fat-soluble extract (containing carnosic acid 65% W / W) and lactose, pass through a 80-mesh sieve, mix well, use 5% starch slurry and 0.15% dodecylsulfonic acid Granulate appropriate amount of sodium mixed slurry, granulate with 20-mesh sieve, dry at 40-60°C, pack separately, and obtain.

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Abstract

The invention discloses application of canosic acid in preparing medicines used for preventing or treating diseases relating to liver injury. Canosic acid can substantially reduce increase of transaminase caused by ischemia reperfusion liver injury or chemical liver injury, obviously improve pathological lesion of liver, inhibit increase of immune factors and the like, has a substantial effect on protecting liver, is applied in preparation of medicines used for preventing or treating diseases relating to liver injury and has the advantages of cheapness and safety.

Description

technical field [0001] The invention relates to a new application of carnosic acid, in particular to an application of carnosic acid in the preparation of drugs for preventing or treating liver damage diseases. Background technique [0002] Liver disease is one of the major diseases that threaten human health in today's society. Many factors, such as chemical poisons, excessive alcohol consumption, and ischemia-reperfusion, can cause liver damage. Eastern countries have a tradition of using Chinese herbal medicine to treat liver diseases in history. Scientific research has also confirmed that the liver-protecting ingredients extracted from natural products have the advantages of high efficiency and low toxicity, but there are relatively few types at present. [0003] Rosemary is a shrub or perennial herb spice plant of Labiatae. It was cultivated in China very early. The Compendium of Materia Medica records that it was introduced from the Western Regions. It is cultivated in...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P1/16
Inventor 田晓峰姚继红高东雁张峰胡艳石磊林木森徐小妹翟晓涵吴航
Owner DALIAN MEDICAL UNIVERSITY
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