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Stepped cannula

A step-by-step, intubation technology, applied in the direction of catheters, trocars, infusion sets, etc., can solve the problems of loss of materials to be delivered, loss of adenovirus vector products, loss, etc.

Inactive Publication Date: 2012-08-08
GENZYME CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Additionally, a substantial portion of the material being delivered is lost due to the large surface area of ​​material exposed to the inside of the cannula
In particular, exposure to stainless steel can result in considerable loss of the material to be delivered
For example, a number of research groups have demonstrated that considerable quantities of adenoviral vector preparations exposed to stainless steel surfaces are lost

Method used

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  • Stepped cannula
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  • Stepped cannula

Examples

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example 1

[0080] Assembly and Packaging Procedures

[0081] A. Typical Intubation #1

[0082] A typical stepped cannula (such as Figure 3A and 3B shown in ).

[0083] Stainless steel pipe sections were cut to length and welded using a Lasag Nd:YAG or NeodiniumYAG (yttrium aluminum garnet) laser (a UV laser in the 454 nm wavelength range). Verify that the weld between the 23G and 19G pipe sections is leak-free and verify that all welded joints withstand a minimum pull force of 10 lbs. The weld between the 23G and 19G tubing sections should be leak-free to prevent any product that might back up outside the needle from leaking into the lumen of the cannula. For the same reason, the glued joint between the exposed distal end of the fused silica tubing and the steel tube portion of the cannula should be fluid-tight.

[0084] Passivate and clean the needle with ultrasound when the laser step is complete. The fused silica tubing was truncated and assembled to the stainless steel cannula ...

example 2

[0103] Delivery of recombinant viral vectors encoding AADC to primate brains

[0104] A recombinant AAV vector encoding human AADC (AAV-hAADC-2) was prepared and delivered to the putamen of rhesus monkeys as follows.

[0105] recombinant vector production

[0106] Recombinant AAV2 was generated by a triple transfection protocol (Matsushita et al. (1998) Gene Ther., 5(7):938-45). Briefly, after cells from the HEK 293 working cell bank were expanded through a series of single-use culture vessels in DMEM containing 10% fetal bovine serum and 2 mM glutamine, the cells were associated with three plasmids (pAAV-hAADC- 2, pHLP19 and pladno5) co-transfection. The rAAV-hAADC-2 vector clone was the same as previously described (Sanftner et al. (2004) Mol. Ther., 9(3):403-9). Plasmids pHLP19 and pladeno5 are more fully described in US Patent Nos. 5,139,941; 5,622,856; 6,001,650 and 6,004,797, the entire disclosures of which are hereby incorporated by reference.

[0107] After an appr...

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Abstract

Described herein are cannulas having a stepped exterior. Also described are methods of making and using these cannulas, for example to deliver one or more materials to the central nervous system of an animal.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 60 / 616,238, filed October 5, 2004, and 60 / 641,551, filed January 4, 2005, both of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention belongs to the field of intubation. In particular, the present invention relates to cannulas for delivering materials, such as bioactive agents, into the central nervous system, to systems comprising such cannulas, and to methods of making and using such cannulas. Background technique [0004] Cannulas can be used to deliver materials into the central nervous system (CNS) of a subject. However, with current cannula designs, care must be taken to prevent backflow of material along the injection trajectory. Quereshi et al. (2000) Neurosurgery 46(3):663-69. Even when precautions are taken to minimize backflow, such as removing the cannula slowly and applying pressure...

Claims

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Application Information

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IPC IPC(8): A61B17/34A61M5/158
CPCA61M2210/0693A61M5/00A61M25/00A61M5/158A61M5/31A61M5/142A61B19/201A61B17/3417A61B17/3478A61B17/3421A61B90/11A61M5/007
Inventor K·班克维茨J·M·萨默
Owner GENZYME CORP