Sphingosine kinase inhibitors

A compound, R19 technology, applied in the field of sphingosine kinase inhibitors, can solve the problem of not identifying the interaction partner
CN102666489BInactive Publication Date: 2014-07-23MERCK PATENT GMBH
24 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Patents(China)
Current Assignee / Owner
MERCK PATENT GMBH
Publication Date
2014-07-23
Estimated Expiration
Not applicable Ā· inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to compounds of formula (I) and their physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers, including their Mixtures in all proportions, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, M1, M2, M3, M4, Y1, Y2, V, W, n, m and o have the meanings given in claim 1.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to sphingosine kinase inhibitors and physiologically acceptable salts, derivatives, prodrugs, solvates, tautomers and stereoisomers thereof for use in the treatment of diseases affected by the inhibition of Sph kinase 1, including mixtures in all their proportions. Background of the invention

[0002] The object of the present invention was to discover new compounds having valuable properties, in particular those which can be used for the preparation of medicaments.

[0003] The present invention relates to compounds and the use of these compounds for the treatment of diseases associated with elevated levels of sphingosine phosphate, and to pharmaceutical compositions comprising these compounds.

[0004] In particular, the present invention relates to compounds of formula (I), which preferably inhibit the enzyme sphingosine kinase 1, which regulates sphingosine phosphate levels through the phosphorylation of sphingosine, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More