Thiazolyl piperdine derivatives

A technology of groups and compounds, applied in the field of thiazolylpiperidine derivatives, can solve problems such as failure to identify interaction partners
CN102066367AInactive Publication Date: 2011-05-18MERCK PATENT GMBH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MERCK PATENT GMBH
Publication Date
2011-05-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R9, R10, R11, Q and W are as defined in claim 1 and precursors thereof are inhibitors of spingosine kinase and can be used, for instance, for the treatment of tumors.
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Description

Background of the Invention

[0001] The object of the present invention is to discover new compounds with valuable properties, especially those which can be used for the preparation of medicaments.

[0002] The present invention relates to compounds and the use of these compounds in the treatment of diseases associated with elevated levels of sphingosine phosphate, and to pharmaceutical compositions comprising these compounds.

[0003] In particular, the present invention relates to compounds of formula I, which preferably inhibit the enzyme sphingosine kinase 1, which regulates sphingosine phosphate levels by phosphorylation of sphingosine, compositions comprising these compounds and the use of these Compounds to treat diseases and complaints such as cancer, tumor formation, growth and spread, arteriosclerosis, ocular diseases, choroidal neovascularization and diabetic retinopathy, inflammatory diseases, arthritis, neurodegeneration, restenosis, cardiac disease, wound healing...

Claims

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