Method for measuring analyte concentration in a liquid sample

Abstract

The blood glucose analysis technique and system described herein address the issue of hematocrit interference when rapidly detecting glucose concentrations. It addresses this issue by using a differential pulse voltammetry technique in which short high, frequency voltage pulses are applied to keep the diffusion layer within the reagent of the working electrode, and the pulses are applied in a limited voltage window (or range) that is below the peak, diffusion-limited current. The readings below the peak are then used to determine glucose concentrations. With this technique, glucose concentrations can be determined relatively fast (e.g., within 5 seconds) and independently of the hematocrit levels of the fluid being analyzed.

Description

Background technique [0001] Recently, there has been a tendency to monitor various health conditions by patients themselves. For example, diabetics traditionally monitor blood sugar levels multiple times a day. By its very nature, glucose monitoring requires a high degree of accuracy in the reported glucose values ​​with little or no interference from other substances contained in the sample. Other types of body fluid tests require similar characteristics. [0002] The most common techniques for measuring glucose levels in blood or interstitial fluid utilize electrochemical techniques. Electrochemical detection of glucose is typically based on the measurement of an electrical signal or property that is proportional to the analyte concentration. This signal is generated when a direct or indirect redox reaction occurs on the electrode surface or in its immediate vicinity. Some traditional electrochemical techniques include amperometry, coulometry and / or impedance measurement...

AI Technical Summary

Problems solved by technology

Although these issues can be addressed using impedance measurement techniques, impedance techniques typically require complex and expensive equipment

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