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Medicament for treating senile dementia and preparation method thereof

A technology of senile dementia and traditional Chinese medicine, which is applied in the field of senile dementia medicine and its preparation, and can solve problems such as no treatment method, failure to delay disease development, insufficient understanding of pathogenesis, etc.

Active Publication Date: 2012-09-19
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the insufficient understanding of the pathogenesis, so far, there is no ideal treatment
FDA-approved drugs include three cholinesterase inhibitors, such as Donepezil, Galantamine, and Rivastigmine, and an excitatory amino acid receptor antagonist, such as memantine (Memantine), which improve short-term symptoms in dementia patients but do not delay disease progression

Method used

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  • Medicament for treating senile dementia and preparation method thereof
  • Medicament for treating senile dementia and preparation method thereof
  • Medicament for treating senile dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Take 10 parts of pinellia, 12 parts of Zhuru, 10 parts of citrus aurantium, 20 parts of Polygonum multiflorum, 6 parts of red ginseng, 10 parts of Chuanxiong, 6 parts of leech, 10 parts of Shichangpu and 10 parts of bamboo ginseng;

[0049] 2. Decoct Pinellia, Bamboo Ru, Citrus Citrus, Polygonum multiflorum, Red Ginseng, Ligusticum Chuanxiong, Leeches, and Shichangpu with water for 3 times, each time for 20 minutes, to extract the medicinal liquid as much as possible, combine the water extracts, and concentrate under reduced pressure to the density It is a thick paste of 1.0-3.0 (50°C), continue drying under reduced pressure to a dry paste, add starch, pulverize, mix evenly, pass through a 80-mesh sieve, wet granulate with 95% ethanol, dry below 80°C, granulate, and prepare into granules.

Embodiment 2

[0051] 1. Take 10 parts of pinellia, 12 parts of Zhuru, 10 parts of aurantium, 20 parts of Polygonum multiflorum, 6 parts of red ginseng, 10 parts of Chuanxiong, 6 parts of leeches and 10 parts of Shichangpu by weight;

[0052] 2. Decoct Pinellia, Bamboo Ru, Citrus Citrus, Polygonum multiflorum, Red Ginseng, Ligusticum Chuanxiong, Leeches, and Shichangpu with water for 3 times, each time for 20 minutes, to extract the medicinal liquid as much as possible, combine the water extracts, and concentrate under reduced pressure to the density It is a thick paste of 1.0-3.0 (50°C).

Embodiment 3

[0054] 1. Prepare by weight 20 parts of Shouwu, 10 parts of Shichangpu, 10 parts of Bamboo Ginseng, 15 parts of Poria cocos, 10 parts of tangerine peel, 10 parts of pinellia, and 6 parts of white mustard seed;

[0055] 2. Decoct Radix Polygoni Multiflori, Shichangpu, Panax Ginseng, Poria, Tangerine Peel, Pinellia, and White Mustard Seed with water for 3 times, each time for 20 minutes, to extract the medicinal liquid as much as possible, combine the water extracts, and concentrate under reduced pressure to the density It is a thick paste of 1.0-3.0 (50°C).

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Abstract

The invention discloses a medicament for treating senile dementia and a preparation method thereof. The medicament consists of active ingredients or pharmaceutically acceptable carriers. The medicament is prepared from the following active ingredients in part by weight: 1 to 15 parts of pinellia tuber, 1 to 15 parts of bamboo shavings, 1 to 15 parts of immature bitter orange, 1 to 15 parts of grassleaf sweelflag rhizome, 1 to 15 parts of thinleaf milkwort root-bark, 1 to 10 parts of ginseng, 1 to 15 parts of ligusticum wallichii and 1 to 20 parts of prepared rehmannia rhizome. The medicament is also prepared from one or more raw materials in part by weight: 1 to 15 parts of Japanese ginseng, 1 to 15 parts of tuckahoe, 1 to 15 parts of dried orange peel, 1 to 10 parts of white mustard seed, 1 to 10 parts of leech and 1 to 20 parts of prepared multiflower knotweed tuber. The medicament can be prepared into formulations such as powder, tablets, capsules, dispersible tablets, pellets, injection, oral liquid and granules. The preparation method comprises the following steps of: chopping raw materials into small pieces or crushing the raw materials into coarse powder, mixing extracts of the raw materials, which are obtained by using water or ethanol, or continuing concentrating to form dry extractum, or mixing the mixture of the extracts and the carriers. Clinical application proves that the medicament is an effective medicament for treating alzheimer's diseases and improving the memory, cognitive disorder and living abilities of patients.

Description

technical field [0001] The invention relates to a medicine for treating senile dementia and a preparation method thereof, more specifically, a medicine for treating senile dementia mainly caused by Alzheimer's disease prepared from Chinese herbal medicine and a preparation method thereof. Background technique [0002] Senile dementia includes types such as Alzheimer's disease (AD) and vascular dementia (VaD). With the acceleration of population aging in my country, the incidence of senile dementia continues to increase, seriously affecting the health of the elderly population. Due to the insufficient understanding of the pathogenesis, so far, there is no ideal treatment. FDA-approved drugs include three cholinesterase inhibitors, such as Donepezil, Galantamine, and Rivastigmine, and an excitatory amino acid receptor antagonist, such as memantine (Memantine), which can improve the symptoms of dementia patients in the short term but cannot delay the progression of the diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P25/28
Inventor 王平孔明望刘玲石和元
Owner HUBEI UNIV OF CHINESE MEDICINE
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