Purification method for lanolin cholesterol

A technology for the purification of lanolin cholesterol and its purification method, which is applied in the field of purification of lanolin cholesterol, can solve the problems of low purity of high-quality goods, inability to remove crude lanolin cholesterol, and inability to meet the market needs of lanolin cholesterol, and achieve simple process and low production cost , easy-to-operate effect

Active Publication Date: 2012-09-26
HENAN LIWEI BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above-mentioned existing crystallization process cannot remove the impurities of crude lanolin cholesterol very well, and the purity of the resulting fine product is still low, which cannot meet the current market demand for high-purity (not less than 99%) lanolin cholesterol in some fields

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1, a method for purifying lanolin cholesterol, is characterized in that: comprise the steps:

[0017] 1) Pickling: Put the crude lanolin cholesterol into the reaction kettle, add 15 times of ethanol, adjust the pH to 3 with sulfuric acid, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization barrel, cool and crystallize, and filter to obtain cholesterol ;

[0018] 2) Alkaline washing: Add the cholesterol in step 1) into the reaction kettle, add 15 times of ethanol, adjust the pH to 12 with sodium hydroxide, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization bucket, cool and crystallize, and filter get cholesterol;

[0019] 3) Neutral washing: put step 2) cholesterol into the reaction kettle, add 15 times of ethanol, adjust the pH to 7 with sodium hydroxide, heat to dissolve at 75°C, add activated carbon with a content of 1.0%, and reflux for 1.5 hours; Filter, and put the ...

Embodiment 2

[0021] 1, a method for purifying lanolin cholesterol, is characterized in that: comprise the steps:

[0022] 1) Pickling: Put the crude lanolin cholesterol into the reaction kettle, add 15 times of ethanol, adjust the pH to 2 with sulfuric acid, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization barrel, cool and crystallize, and filter to obtain cholesterol ;

[0023] 2) Alkaline washing: Add the cholesterol in step 1) into the reaction kettle, add 15 times of ethanol, adjust the pH to 13 with sodium hydroxide, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization bucket, cool and crystallize, and filter get cholesterol;

[0024] 3) Neutral washing: Add cholesterol in step 2) into the reaction kettle, add 15 times of ethanol, adjust the pH to 8 with sodium hydroxide, heat to dissolve at 75°C, add activated carbon with a content of 1.5%, and reflux for 1.5 hours; Filter, and put t...

Embodiment 3

[0026] 1, a method for purifying lanolin cholesterol, is characterized in that: comprise the steps:

[0027] 1) Pickling: Put the crude lanolin cholesterol into the reaction kettle, add 20 times of ethanol, adjust the pH to 4 with sulfuric acid, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization barrel, cool and crystallize, and filter to obtain cholesterol ;

[0028] 2) Alkaline washing: Add the cholesterol in step 1) into the reaction kettle, add 20 times of ethanol, adjust the pH to 10 with sodium hydroxide, heat to dissolve, the temperature is 75°C, and reflux for 1.5 hours; put it into the crystallization bucket, cool and crystallize, and filter get cholesterol;

[0029] 3) Neutral washing: Add cholesterol in step 2) into the reaction kettle, add 20 times of ethanol, adjust the pH to 7 with sodium hydroxide, heat to dissolve at 75°C, add activated carbon with a content of 1.5%, and reflux for 1.5 hours; Filter, and put t...

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PUM

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Abstract

The invention discloses a purification method for lanolin cholesterol. The method includes three steps: acid cleaning, alkaline cleaning and neutral cleaning. The purity of crude lanolin cholesterol reaches 99.3 percent after going through the purification process, an increase of 8.5 percent when compared with existing purities in the market, and can meet market requirements on high-purity lanolin cholesterol. The purification method for the lanolin cholesterol has the advantages of high product quality, ordinary and easy-obtained raw materials, low production cost, consumption and pollution, simplicity in process, easiness in operation, suitableness for purification of large-scale production of the lanolin cholesterol and the like, so that market requirements on the high-purity lanolin cholesterol are met.

Description

technical field [0001] The invention belongs to the field of organic chemistry and relates to a method for purifying lanolin cholesterol. Background technique [0002] At present, lanolin cholesterol developed and produced both at home and abroad is purified by recrystallization in ethanol, with a purity of about 90%. For example, Zhu Jingke and Shao Junfang recrystallized crude lanolin cholesterol to obtain cholesterol crystals with a purity of 90%; Yang Yiwen from Zhejiang University crystallized crude lanolin cholesterol in alcohol to obtain refined cholesterol with a purity of 95%; Tan Lanlan from Sichuan University also obtained crude lanolin cholesterol with a purity of 95%. Lanolin cholesterol is recrystallized to obtain cholesterol crystals with a purity of 90%. [0003] The above-mentioned existing crystallization process cannot remove the impurities of crude lanolin cholesterol well, and the purity of the resulting refined product is still low, which cannot meet t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
Inventor 薛家禄马志军
Owner HENAN LIWEI BIOLOGICAL PHARMA
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