Formula of aureomycin hydrochloride premix granule and granulating process

Abstract

The invention discloses a formula of aureomycin hydrochloride premix granule, which is characterized in that the following components are included: 80 percent or less than 80 percent of aureomycin hydrochloride, 80 percent or less than 80 percent of soluble starch or starch degradation products, 20 percent or less than 20 percent of carbohydrates, and 30 percent or less than 30 percent of purified water. The invention further discloses a granulating process. After the adoption of the formula and the granulating process, the invention achieves that the aureomycin hydrochloride premix granule is uniform, has a mellow appearance, is unanimous in tincture and high in percentage of ripened grains, the stability of product quality is excellent, the normal working conditions during the aureomycin hydrochloride premix granulating process can be ensured, and the improvement to production efficiency and quality is facilitated.

Description

technical field [0001] The invention relates to the field of production of chlortetracycline hydrochloride, in particular to a formula and a granulation process of chlortetracycline hydrochloride premix granules. Background technique [0002] In the dry granulation process of aureomycin hydrochloride premix granules, a hydraulic pressure wheel is used to compress the material and the sieved returned powder, and then the product is obtained by crushing and sieving. Heat-sensitive chlortetracycline hydrochloride causes the loss of effective components, and also increases the impurity components of the product, decreases the stability of the product, and uneven color of the product. At the same time, the shape of the particles lacks uniformity and roundness through flaky crushing and granulation. , because the production of premixes has certain requirements on cleanliness, the whole production process must be carried out in a clean workshop, and dust will be generated during th...

AI Technical Summary

Problems solved by technology

[0002] In the dry granulation process of aureomycin hydrochloride premix granules, a hydraulic pressure wheel is used to compress the material and the sieved returned powder, and then the product is obtained by crushing and sieving. Heat-sensitive chlortetracycline hydrochloride causes the loss of effective components, and also increases the impurity components of the product, decreases the stability of the product, and uneven color of the product. At the same time, the shape of the particles lacks uniformity and roundness through flaky crushing and granulation. , because the production of premixes has certain requirements on cleanliness, the whole production process must be carried out in a clean workshop, and dust will be generated during the batching, crushing, granulation and product collection processes, which will pollute the workshop and the surrounding environment, seriously affecting Its cleanliness also has a great impact on the physical and mental health of operators

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