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Pharmaceutical composition

A composition and drug technology, applied in the field of medicine, can solve problems such as unfavorable use of preparations, and achieve the effects of clear ingredients, controllable quality, and good therapeutic effect

Active Publication Date: 2012-10-10
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above ingredients have been proven to be effective against HPV infection, but due to the large number of HPV subtypes, each subtype has differences in virus phenotype, growth characteristics, pathogenicity, sensitivity to drugs, and clinical prognosis, so a single ingredient Not likely to be effective against all subtypes, so single-ingredient preparations are not conducive to clinical use

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0137] Prescription: Gemacerone 15g, Furandiene 39g, Curdione 24g, β-Elemene 9g, Curcumol 8g, Borneol 75g.

[0138] Dosage form: suppository.

[0139] Preparation method: Mix Gemacerone, Furandiene, Curdione, β-Elemene, Curcumol and 75g polysorbate 80 (Tween-80) in the prescribed amount, dissolve 75g of borneol with an appropriate amount of ethanol, and mix with Mix the above solution.

[0140] The polyoxyethylene stearate 1491g of prescription quantity is put on the water bath and is heated and melted, adds above-mentioned medicinal liquid, stirs, filling, makes 1000 suppositories.

Embodiment 2-8

[0142] Prepare the suppository according to the following prescription, and the preparation method is the same as in Example 1.

[0143] Example

Embodiment 9

[0145] Prescription: Gemacerone 6.5g, Furandiene 32g, Curdione 21g, β-Elemene 9.5g, Curcumol 2.5g, Borneol 35g.

[0146] Dosage form: effervescent tablet.

[0147] Preparation:

[0148] 1) Take β-cyclodextrin, add appropriate amount of water at 25ml / g, stir to make it completely dissolved, and heat if necessary to obtain β-cyclodextrin solution; - Elemene, curcumol, borneol, diluted with absolute ethanol, slowly added to the β-cyclodextrin solution, continued to stir until a homogeneous phase was formed, placed in the refrigerator overnight, filtered with suction, washed 3 times with a small amount of petroleum ether, and frozen , in white powder.

[0149] 2) Mix the above-mentioned white powder with 35g of borneol, 150g of citric acid and 160g of lactose; take another 120g of sodium bicarbonate and 160g of lactose, mix them evenly, and use 5% PVP absolute ethanol solution as a binder to granulate, at 50°C Dry, granulate, add appropriate amount of PEG6000, mix well, and pre...

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Abstract

The invention belongs to the technical field of medicines and provides a pharmaceutical composition. The pharmaceutical composition comprises germacrone, furanodiene, curdione, beta-elemene, curcumol, curzerene and borneol. The components of the pharmaceutical composition are definite, and the quality can be controlled. The pharmaceutical composition can be used for preparing vaginal or rectal preparations and has a good effect of treating HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) infection and cervical diseases and can be used widely clinically.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] Human papillomavirus (HPV) is a kind of papillomavacuolating virus A belonging to Papovaviridae. It is a spherical DNA virus that can cause squamous epithelial proliferation of human skin and mucous membranes. At present, more than 130 kinds have been isolated, and different subtypes cause different clinical manifestations and invade different tissue parts. According to the classification of cancer, it can be divided into low-risk HPV and high-risk HPV. HPV has strong resistance and can withstand drying and long-term storage. It can be inactivated by heating or treated with formalin, so it can be inactivated by high-temperature disinfection and 2% glutaraldehyde disinfection. HPV mainly includes 13 subtypes, which are c...

Claims

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Application Information

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IPC IPC(8): A61K31/35A61P15/02A61P31/20A61P35/00A61K31/015A61K31/045A61K31/122A61K31/343
Inventor 陈容徐扬冯仲异黄娴
Owner HAINAN BIKAI PHARM CO LTD
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