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Application of mulberroside to preparation of diuretic medicine

A technology of mulberry glycoside and medicine, applied in the field of chemistry, can solve the problems such as the unseen monomer compound mulberry glucoside, and achieve the effects of increasing the urine volume of rabbits, low side effects, and mild diuretic effect.

Inactive Publication Date: 2012-10-24
CATCH BIO SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report that the monomeric compound mulpertin is used for the preparation of diuretics

Method used

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  • Application of mulberroside to preparation of diuretic medicine
  • Application of mulberroside to preparation of diuretic medicine
  • Application of mulberroside to preparation of diuretic medicine

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Embodiment Construction

[0024] The following examples can enable those skilled in the art to understand the present invention more fully, but do not limit the present invention in any way.

[0025] Experimental animals: rabbits, (2±0.2) kg, male.

[0026] Drug configuration: the compound mosbaritin with a purity of 98% to 100% is evenly dispersed in water to prepare three concentrations of mosbaritin solutions for intragastric administration, which are divided into low-dose groups of 1 mg / mL, middle-dose groups The dose group was 2 mg / mL, the high dose group was 4 mg / mL; the active drug furosemide was 4 mg / kg.

[0027] Experimental model: Rabbit animal model.

[0028] Experimental method: 40 rabbits were randomly divided into 5 groups, 8 in each group, which were blank group, positive drug group, high-dose drug group, middle-dose drug group, and low-dose drug group. The high-dose drug group, the middle-dose group, and the low-dose group were administered 40 mL / kg respectively; the positive drug gro...

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Abstract

The invention belongs to the field of pharmaceutical chemistry, and provides application of mulberroside to preparation of diuretic medicine. The mulberroside has a structure of 3-[2-(4-(beta-D-glucopyranosyl-O-2-hydroxyphenyl)]-(E)-vinyl]-5-hydroxyphenyl-beta-D-glucopyranoside. The invention also provides a diuretic medical composition, which comprises mulberroside with an effective amount and pharmaceutically acceptable carrier. Research by the invention shows that mulberroside has the effect to increase urine amount of rabbits, and has characteristics of mild diuretic effect and persistency.

Description

technical field [0001] The invention relates to the chemical field, in particular to the stilbene glycoside monomer compound Mulberroside A (Mulberroside A), especially the application of Mulberroside A in the preparation of diuretic drugs. Background technique [0002] Clinical data show that because the elderly often suffer from high blood pressure, heart disease, liver, kidney and other diseases, about 10% of them need to take diuretics frequently to discharge the retained water in the body, reduce the burden on the heart, or eliminate various diseases. cause of edema. [0003] Diuretics are a class of drugs that act directly on the kidneys. By inhibiting the reabsorption of renal tubules, they increase the excretion of electrolytes, especially sodium ions and water, and increase urine output, so they are also called natriuretic diuretics. The clinical use of diuretics mainly has the following four aspects: 1. Edema caused by various reasons. 2. As a basic antihypertens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P7/10
Inventor 温尧林
Owner CATCH BIO SCI & TECH