Application of ophiopogon polysaccharide extract in preparing foodstuff additives, health-care products or medicines with weight-reducing function

A technology for food additives, Ophiopogon japonicus polysaccharides, applied in the application, food preparation, drug combination and other directions

Inactive Publication Date: 2012-10-31
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no literature report that the polysaccharide extract of Ophiopogon japonicus with a peak molecular weight in the range of 3000-6500 has weight loss

Method used

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  • Application of ophiopogon polysaccharide extract in preparing foodstuff additives, health-care products or medicines with weight-reducing function
  • Application of ophiopogon polysaccharide extract in preparing foodstuff additives, health-care products or medicines with weight-reducing function
  • Application of ophiopogon polysaccharide extract in preparing foodstuff additives, health-care products or medicines with weight-reducing function

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Ophiopogon japonicus polysaccharide extract (peak molecular weight 5000~6500)

[0017] 1) Extraction of Ophiopogon japonicus total polysaccharides:

[0018] Take 1 kg of dried Ophiopogon japonicus tuber, flatten it with 5-6 times the weight of 80% ethanol and reflux 3 times, each time for 1 hour, and extract the dregs with water 2-3 times, each time for 30 minutes. Concentrate the water extract to 1g / ml under reduced pressure, add 95% ethanol until the alcohol content reaches 60%-80%, let it stand overnight, pour off the supernatant, repeat the alcohol precipitation once for precipitation, and freeze-dry to obtain light yellow wheat Winter polysaccharide powder;

[0019] 2) Purification of Ophiopogon japonicus polysaccharide extract (peak molecular weight 5000-6500):

[0020] The total polysaccharides of Ophiopogon japonicus were taken, dissolved in water, and centrifuged to remove the precipitate. Add 1-2 times the volume of 70%-95% e...

Embodiment 2

[0021] The preparation of embodiment 2 Ophiopogon japonicus polysaccharide extract (peak molecular weight 4000~5000)

[0022] 1) Extraction of Ophiopogon japonicus total polysaccharides:

[0023] Take the dried Radix Ophiopogon japonicus root, reflux 3 times with 5-6 times the weight of 70%-95% ethanol, discard it, extract the dregs with water 2-3 times, concentrate the water extract to 0.5-1g / ml under reduced pressure, add 75% -95% ethanol until the alcohol content reaches 60%-80%, let it stand overnight, pour off the supernatant, repeat the alcohol precipitation once for precipitation, and dry to obtain light yellow total polysaccharide powder of Ophiopogon japonicus;

[0024] 2) Purification of Ophiopogon japonicus polysaccharide extract (peak molecular weight 4000-5000):

[0025] The total polysaccharides of Ophiopogon japonicus were taken, dissolved in water, and centrifuged to remove the precipitate. Add 1-2 times the volume of 70%-95% ethanol to the supernatant to pre...

Embodiment 3

[0026] The preparation of embodiment 3 Ophiopogon japonicus polysaccharide extract (peak molecular weight 3000~4000)

[0027] 1) Extraction of Ophiopogon japonicus total polysaccharides:

[0028] Take the dried Radix Ophiopogon japonicus root, reflux 3 times with 5-6 times the weight of 70%-95% ethanol, discard it, extract the dregs with water 2-3 times, concentrate the water extract to 0.5-1g / ml under reduced pressure, add 75% -95% ethanol until the alcohol content reaches 60%-80%, let it stand overnight, pour off the supernatant, repeat the alcohol precipitation once for precipitation, and dry to obtain light yellow total polysaccharide powder of Ophiopogon japonicus;

[0029] 2) Purification of Ophiopogon japonicus polysaccharide extract (peak molecular weight 3000-4000):

[0030] The total polysaccharides of Ophiopogon japonicus were taken, dissolved in water, and centrifuged to remove the precipitate. Add 1-2 times the volume of 70%-95% ethanol to the supernatant to pre...

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Abstract

The invention discloses an application of an ophiopogon polysaccharide extract (with peak top molecular weight of 3000-6500) in preparing foodstuff additives, health-care products or medicines with a weight-reducing function. According to the invention, abdominal obesity mice models are used in experiments for inspecting the inhibiting effect of the ophiopogon polysaccharide extract upon obese mice weight increasing, and the weight-reducing function of the ophiopogon polysaccharide extract is evaluated. The embodiment of the invention and animal experiment results proof that the ophiopogon polysaccharide extract has a substantial weight-reducing function. Therefore, the ophiopogon polysaccharide extract can be used for preparing foodstuff additives, health-care products or medicines with the weight-reducing function.

Description

technical field [0001] The invention relates to a new application of an extract of Ophiopogon japonicus polysaccharides, in particular to an application of an extract of Ophiopogon japonicus polysaccharides in preparing food additives, health care products or medicines with weight loss function. Background technique [0002] Obesity is a nutritional metabolic disorder disease caused by the joint action of genetic factors and environmental factors, and is the main cause of chronic diseases. Often accompanied by insulin resistance and hyperinsulinemia, it can induce a variety of metabolic dysfunction related to cardiovascular disease, and increase the risk of type II diabetes, coronary heart disease, stroke, congestive heart failure, hypertension, and dyslipidemia , sleep apnea syndrome, and the morbidity and mortality of certain cancers (such as ovarian cancer, thymus cancer, and colon cancer). [0003] Yin-nourishing traditional Chinese medicines have the functions of Sheng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A23L1/09A61K31/715A61P3/04
CPCA61K31/715A61K36/8968A61K2236/00A61P3/04A61P31/04
Inventor 冯怡徐德生阮克锋王硕林晓梁爽王源
Owner SHANGHAI UNIV OF T C M
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