Novel osteoporosis resistant use of carnosol

Abstract

The invention discloses a novel use of carnosol for preventing and treating osteoporosis. Osteoporosis is one of the important diseases harming human health. With the aging of population, the number of patients suffering the osteoporosis is growing increasingly, so that huge social, medical and economic burdens are brought to the whole world. Although relevant experts and scholars at home and abroad pay much attention to the prevention and treatment of the disease, no effective therapeutic drug for the disease exist yet. The invention finds that the carnosol has a remarkable osteoporosis resistant effect via an in-vivo test. The test result shows that the carnosol can inhibit the enhancement of bone turnover rate caused by de-ovary, bring less destruction to the bone, can simultaneously improve blood calcium concentration and be favorable for the deposition of the bone. The carnosol has a therapeutic effect for the osteoporosis caused by oestrogen lack with no oestrogen-induced side effects.

Description

technical field [0001] The invention relates to the field of drugs related to anti-osteoporosis, in particular to the new application of carnosol for preventing and treating osteoporosis. Background technique [0002] Osteoporosis is a systemic, metabolic bone disease characterized by reduction and loss of bone mass, bone fragility and increased risk of fracture. With the aging of the population, the incidence of osteoporosis has also increased rapidly, and it has become an important disease that endangers human health and has brought a huge social and economic burden to the world. Although relevant experts and scholars at home and abroad attach great importance to the prevention and treatment of this disease, there is still a lack of effective therapeutic drugs for this disease. [0003] At present, commonly used clinical drugs for the prevention and treatment of osteoporosis include estrogen replacement drugs, bisphosphonates, selective estrogen receptor modulators, vitam...

AI Technical Summary

Problems solved by technology

Although bisphosphonates are effective, they can cause serious adverse reactions such as osteonecrosis of the jaw, musculoskeletal pain, and renal failure; although hormone replacement therapy is an important method to prevent and treat postmenopausal osteoporosis, long-term use can cause breast cancer , endometrial cancer potential risk and increased risk of thrombosis; selective estrogen receptor modulators can significantly increase thrombotic events

Other drugs are either expensive or have uncertain long-term curative effects, which are not ideal