Method for the electrochemical measurement of an analyte concentration in vivo, and fuel cell for this purpose

A fuel cell and analyte technology, which is applied in biochemical fuel cells, biochemical equipment and methods, analytical materials, etc., can solve the problems of removing sensors on fire, and achieve the effect of simple cost and consumption avoidance

Active Publication Date: 2012-11-14
F HOFFMANN LA ROCHE & CO AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

If this intermediate product escapes from the sensor, this ca

Method used

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  • Method for the electrochemical measurement of an analyte concentration in vivo, and fuel cell for this purpose
  • Method for the electrochemical measurement of an analyte concentration in vivo, and fuel cell for this purpose
  • Method for the electrochemical measurement of an analyte concentration in vivo, and fuel cell for this purpose

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Example Embodiment

[0046] figure 1 The sensor shown in works according to the principle of a fuel cell. The analyte to be measured, such as glucose or lactic acid (Lactat), produces a redox amphoteric product, which forms the fuel for the fuel cell. Therefore, the greater the concentration of the analyte to be measured, the greater the energy provided by the fuel cell. Therefore, the voltage drop across the load resistance between the anode and the cathode can be used as a measurement signal for determining the analyte concentration.

[0047] in figure 1 Top view of China and Israel and in figure 2 The sensor shown in the longitudinal section has an anode 1 and a cathode 2 which are covered by a common enzyme layer 3. The anode 1 and the cathode 2 are respectively located at the ends of conductor lines 5, 6 arranged on a carrier 4 (for example, a plastic sheet). The conductor lines 5 and 6 may be made of noble metal (for example, palladium), which may also form the surface of the cathode 2. The...

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Abstract

The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer (3) and which supplies an electrical voltage, dependent on the analyte concentration to be measured, between an anode (1, 1a, 1b) and a cathode (2, 2a, 2b), which voltage is measured. According to the invention, provision is made that, in the catalytic reaction of the analyte to be measured in the enzyme layer (3), a product is generated which, as fuel of the fuel cell, oxidizes on the anode (1, 1a, 1b) and is reduced on the cathode (2, 2a, 2b). The invention further relates to a fuel cell for such a method.

Description

technical field [0001] The invention is based on a method having the features stated in the preamble of claim 1 . Background technique [0002] From US Pat. No. 3,837,339 it is known to use fuel cells as electrochemical sensors for the in vivo measurement of analyte concentrations, for example glucose concentrations. Here, the analyte to be measured is converted catalytically into fuel for the fuel cell. The fuel cell described in US Pat. No. 3,837,339 oxidizes glucose at the anode and produces gluconic acid there. Oxygen reduction at the cathode. [0003] In order to improve the efficiency of these reactions, it is known to equip the cathode with an enzyme layer containing enzymes for the catalytic conversion of the analyte and to apply an enzyme layer with enzymes for the catalytic reduction of oxygen on the anode. Such a fuel cell is known, for example, from US 2005 / 0118494 A1. In the case of these fuel cells, the anode is covered with an enzyme layer comprising gluco...

Claims

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Application Information

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IPC IPC(8): A61B5/00C12Q1/00H01M8/16
CPCC12Q1/006H01M8/16A61B5/1486A61B5/14532Y02E60/527C12Q1/001Y02E60/50G01N27/3271
Inventor G.奥克菲尔克K-H.克尔克
Owner F HOFFMANN LA ROCHE & CO AG
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