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Applications of diagnostic markers in biliary atresia of newborns

A diagnostic marker, a technique for biliary atresia, which is applied in the biological field to achieve the effect of improving the curative effect of surgery

Inactive Publication Date: 2012-12-12
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the diagnostic markers for neonatal biliary atresia

Method used

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  • Applications of diagnostic markers in biliary atresia of newborns
  • Applications of diagnostic markers in biliary atresia of newborns
  • Applications of diagnostic markers in biliary atresia of newborns

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Embodiment 1

[0022] The present invention relates to diagnostic markers for diagnosing biliary atresia in newborns and for distinguishing biliary atresia from other cholestatic diseases of infants, including infantile hepatitis syndrome, cytomegalovirus hepatitis and choledochal cyst.

[0023] The main bile acids in human blood include cholic acid, glycocholic acid, taurocholic acid, chenodeoxycholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, deoxycholic acid, glycodeoxycholic acid Cholic acid, taurodeoxycholic acid, ursodeoxycholic acid, glycursodeoxycholic acid, tauroursodeoxycholic acid, lithocholic acid, glycinolithocholic acid, taurolithocholic acid. 14 major bile acids (cholic acid, glycocholic acid, taurocholic acid, chenodeoxycholic acid, glycochenodeoxycholate) in biliary atresia, infantile hepatitis syndrome, cytomegalovirus hepatitis and choledochal cyst Acid, Taurochenodeoxycholic Acid, Deoxycholic Acid, Glycodeoxycholic Acid, Taurodeoxycholic Acid, Ursodeoxy...

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Abstract

The invention relates to applications of serum taurochenodeoxycholic acid and chenodeocycholic acid as diagnostic markers in the preparation of medical instruments for diagnosing biliary atresia of newborns. The diagnostic markers of the medical instruments are content ratio of the taurochenodeoxycholic acid and the chenodeocycholic axid in serum. The invention also provides the application of chenodeocycholic acid. The application of diagnostic markers in biliary atresia of the newborns has the advantages that the application of the taurochenodeoxycholic acid and the chenodeocycholic acid as diagnostic markers of biliary atresia is proposed for the firstly time, so that the biliary atresia can be distinguished from other cholestasis diseases of newborns, the best operation time of children can be strived for, and therefore, the operation effect can be improved.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular, it is a diagnostic marker for diagnosing neonatal biliary atresia and distinguishing biliary atresia from other infantile cholestasis diseases (including infantile hepatitis syndrome, cytomegalovirus hepatitis and choledochal cyst) Applications. Background technique [0002] Biliary atresia (BA) is a destructive neonatal biliary inflammatory fibrous obstruction, affecting different lengths of intrahepatic and extrahepatic bile ducts, is the most common cause of obstructive jaundice in newborns, and is also the most common cause of pediatric liver transplantation , 40-50% of children's liver transplantation is caused by this. [0003] Portojejunostomy (Kasai radical operation) is the treatment of choice for biliary atresia. The operation time has a great influence on the curative effect of Kasai operation. The study found that Kasai surgery performed within 60 days of birth was assoc...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 周科军蔡威琳娜顾学范陈颖伟
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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