Photoelectrode array for neuron stimulation and electric signal recording and preparing method of array
A technology of electrical signals and neurons, applied in the direction of material analysis, measuring devices, instruments, etc. through electromagnetic means, can solve the problem that it is difficult for the light outlet and the electrical recording point to meet the consistency of the optical stimulation site and the electrical recording site, and there is no simultaneous Stimulation, influence on nerve signal analysis results and other issues, to achieve the effect of low cost, consistency and simple process
Inactive Publication Date: 2012-12-19
INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI
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Problems solved by technology
In the past, the photoelectrodes were firstly prepared with electrical recording points before assembling or preparing the light guide layer. In order not to hinder the signal collection function of the electrical recording points, the light guide layer will keep a certain distance from the electrode points, so the light outlet and the electrical recording points It is difficult to meet the consistency between the photo-stimulation site and the electrical recording site, which also means that there are certain differences between the stimulated cells and the recorded cells
This unclear stimulus-response causality affects the analysis of neural signals
In addition, most of the existing photoelectrodes have only one optical waveguide, which does not meet the conditions for simultaneous stimulation when faced with the different effects of light sources in various wavelength bands on the nerves.
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[0023] see figure 1 As shown, the present invention provides a photoelectrode array for neuron stimulation and electrical signal recording, including:
[0024] A plurality of waveguide structures 10, the waveguide structure 10 is generally cylindrical, and the front end is tapered, which is convenient for insertion into the tissue during body implantation and reduces tissue damage. The number of the waveguide structures 10 is greater than 1, and each waveguide structure 10 is a three-layer structure, including from inside to outside: a waveguide layer 11, a conductive layer 12 deposited on the upper surface of the waveguide layer 11, and an insulating layer 13 with uniform thickness deposited on the waveguide layer 11 and the conductive layer 12, The material of the waveguide layer 11 is an optical fiber made of silica or plastic, and the principle of total reflection of light is used to confine the light in the waveguide to be responsible for the transmission of light. The ma...
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A photoelectrode array for neuron stimulation and electric signal recording comprises a plurality of waveguide structures, a connector and a PCB (Printed Circuit Board), wherein the plurality of waveguide structures are cylindrical; the connector is rectangular, a plurality of connecting holes are formed in one surface of the connector; the waveguide structures are plugged in the connecting holes of the connector; and the PCB (Printed Circuit Board) is L-shaped, and the long edge of the PCB is fixed to the root parts of the waveguide structures. The photoelectrode array has the advantages of being capable of connecting a plurality of light sources simultaneously to perform optical simulation in different wave bands, and further simple to prepare and good in compatibility.
Description
technical field [0001] The invention relates to the field of electrode sensor design and processing for biological nerve stimulation and electrical signal detection, and more specifically relates to a photoelectrode array and a preparation method for neuron stimulation and electrical signal recording based on optogenetics in biomedical engineering. Background technique [0002] Elucidating the fundamental processes of neural activity is one of the goals of modern brain science. When analyzing how nerve cells perform various functions, it is often necessary to activate or inhibit specific cells to determine their role in complex neural circuits. Optogenetics, which has developed rapidly in recent years, can excite or inhibit certain types of nerve cells to specific wavelengths of light. The use of photoelectrodes to stimulate neurons with light and to record electrical signals has gradually become the main research method. [0003] Currently commonly used photoelectrode str...
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Inventor 裴为华陈三元归强李雷陈弘达
Owner INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI