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Application of Gypensapogenin A in medicine for preventing human fungi

A technology against human fungi and drugs, applied in the direction of antifungal agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc. Active effect

Active Publication Date: 2014-04-16
启东市天汾电动工具技术创新中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Gypensapogenin A in medicine for preventing human fungi
  • Application of Gypensapogenin A in medicine for preventing human fungi
  • Application of Gypensapogenin A in medicine for preventing human fungi

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound Gypensapogenin A tablet involved in the present invention:

[0014] Take 20 grams of compound Gypensapogenin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0015] Embodiment 2: The preparation of the compound Gypensapogenin A capsules involved in the present invention:

[0016] Get 20 grams of compound Gypensapogenin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0018] Experimental example: Gypensapogenin A anti-human fungal activity

[0019] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens include Trichomonas rubrum, Microsporum lanoides and Phytophthora clematis, and the concentration of the bacterial solution is 10 5 individual / mL. The initial concentration of Gypensapogenin A was 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it was serially diluted to 0.098 μg / mL. The same volume of bacterial liquid and test samples were mixed and cultured in a 96-well plate. The human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the anti-fungal results of Gypensapogenin A are shown in Table 1.

[0020] Table 1 Gypensapogenin A anti-human fung...

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Abstract

The invention discloses application of Gypensapogenin A in preparing a medicine for preventing human fungi, belonging to the medicine field. Gypensapogenin a has strong inhibiting functions on trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that Gypensapogenin A can be used as a compound for resisting human fungi, and can be applied for preparing relative medicine. The application of Gypensapogenin A in preparing the medicine for preventing human fungi, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the human fungus inhibiting activity of Gypensapogenin A is extremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin A has outstanding actual characteristics. Meanwhile, Gypensapogenin A has outstanding progress when being used for preventing and treating human fungus infection.

Description

technical field [0001] The present invention relates to the use of Gypensapogenin A, in particular to the application of Gypensapogenin A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Gypensapogenin A in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P31/10
Inventor 王慧张广吴俊华
Owner 启东市天汾电动工具技术创新中心
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