Compounds and therapeutic uses thereof

一种化合物、溶剂合物的技术，应用在药物化学领域，能够解决细胞死亡、消耗等问题

Inactive Publication Date: 2013-01-09
MYREXIS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be understood that the reduction of intracellular NAD by Nampt inhibitors + levels can lead to depletion of ATP and eventually cell death

Method used

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  • Compounds and therapeutic uses thereof
  • Compounds and therapeutic uses thereof
  • Compounds and therapeutic uses thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0028] 1. Definition

[0029]The term "alkyl" as used herein by itself or as part of another group refers to a saturated aliphatic straight chain or branched chain group having from 1 to 20 carbon atoms (whenever Herein, a numerical range such as "1~20" refers to each integer in the given range; for example, "1~20 carbon atoms" means that the alkyl group can consist of 1, 2 or 3 carbon atoms, or more carbon atoms, up to a total of 20). Alkyl groups may be unsubstituted or have one or more substituents (typically 1 to 3 substituents, except in the case of halogen substituents, eg perchloro). For example, C 1-6 Alkyl refers to an aliphatic hydrocarbon straight chain or branched chain group alkyl containing 1-6 carbon atoms (such as including methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, 3-pentyl and hexyl, etc.), which may optionally have substituents.

[0030] The term "lower alkyl" as used herein refers to an alkyl group having 1 to 6 carbon atoms.

[00...

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Abstract

The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.

Description

technical field [0001] The present invention generally relates to the field of medicinal chemistry, and specifically, the present invention provides compounds capable of inhibiting phosphoribosyltransferase (Nampt). The present invention also provides methods for preparing these compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to treat diseases, especially cancers, systemic and chronic inflammations, rheumatoid arthritis, and diabetes mellitus that are sensitive to inhibiting Nampt , obesity, T cell-mediated autoimmune diseases, ischaemia, and other complications of these diseases. technical background [0002] Phosphoribosyltransferase (Nampt; also known as visfatin and precursor B cell clone enhancer factor 1 (PBEF)) catalyzes the condensation of nicotinamide (NaM) 5-phosphoribosyl-1-pyrophosphate to nicotinamide mononucleotide. This is the first and rate-limiting step in the biosynthetic pathway of the cell to make ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/28
CPCC07D231/40C07D471/04C07D213/75C07D215/46C07C275/32C07C311/21C07D409/12C07D317/58C07C275/30C07D261/08C07D413/12C07D307/52C07C275/40C07C275/28C07D213/42C07D333/20C07C311/47C07D401/12C07D307/14C07C275/34C07D235/06C07D231/12C07D209/14C07D213/65C07D213/40C07D213/61C07D213/71C07D213/73C07D213/74C07D213/89C07D213/53C07D213/64C07D333/22C07D417/12C07D213/68C07D233/64C07D307/48C07D237/20A61P19/02A61P29/00A61P3/04A61P35/00A61P37/06A61P43/00A61P9/10A61P3/10C07D213/72A61K31/44C07B2200/05
Inventor A·J·威拉德森J·W·洛克曼B·R·墨菲W·R·贾德I·C·金S·H·金D·F·字嘎K·M·耶格T·C·弗莱舍R·T·特瑞洛伦佐J·J·博尼费斯D·P·派克I·A·麦克亚历山大M·G·博尔散维奇D·M·达斯特拉普
Owner MYREXIS INC
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