Application of Gypensapogenin B to preparing drugs for resisting human funguses

A technology against human fungi and drugs, which is applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as digestive tract irritation and strong accumulation of toxicity, and achieve outstanding substantive features and human fungal inhibition Active effect

Active Publication Date: 2013-06-19
南通三聚知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Gypensapogenin B to preparing drugs for resisting human funguses
  • Application of Gypensapogenin B to preparing drugs for resisting human funguses
  • Application of Gypensapogenin B to preparing drugs for resisting human funguses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound Gypensapogenin B tablet involved in the present invention:

[0014] Take 20 grams of compound Gypensapogenin B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0015] Embodiment 2: the preparation of the compound Gypensapogenin B capsules involved in the present invention:

[0016] Take 20 grams of compound Gypensapogenin B, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0018] Experimental example: Gypensapogenin B anti-fungal activity in humans

[0019] Anti-human fungus activity experiment is the method of concentration dilution, each measurement is repeated three times, the test pathogens include Trichomonas rubrum, Microsporum lanoides and Phytophthora clematis, and the concentration of bacteria solution is 10 5 individual / mL. The initial concentration of Gypensapogenin B was 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it was serially diluted to 0.098 μg / mL. The equal volume of bacterial liquid and test samples were mixed and cultured in a 96-well plate. The human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the anti-fungal results of Gypensapogenin B are shown in Table 1.

[0020] Table 1 MIC value of Gypensapogenin B agai...

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Abstract

The invention relates to application of Gypensapogenin B to preparing drugs for resisting human funguses, belonging to the field of medicines. Gypensapogenin B has very strong effect on inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, therefore, Gypensapogenin B can serve as a compound capable of resisting the human funguses and is expected to be applied to preparingrelated drugs. The application of Gypensapogenin B to preparing the drugs for resisting the human funguses, disclosed by the invention, is firstly published, the framework type is brand new, the activity of inhibiting the human funguses is unexpectedly strong and the probability of giving any revelation by other compounds does not exist, so that prominent substantive features are provided and a remarkable progress in preventing and treating the human fungus infection is made at the same time.

Description

technical field [0001] The present invention relates to the application of Gypensapogenin B, in particular to the application of Gypensapogenin B in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Gypensapoge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P31/10
Inventor 吴俊艺王泽正吴俊华
Owner 南通三聚知识产权服务有限公司
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