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Medicine compound for treating osteoporosis and osteoporosis fracture

An osteoporosis and composition technology, which is applied to the pharmaceutical composition of osteoporotic fractures, Huoxue Busui Shengguling Granules, in the field of treatment of osteoporosis, can solve the problem of high risk of osteoporotic fractures, high risk of surgical treatment of osteoporotic fractures, Side effects and complications

Active Publication Date: 2013-01-16
南通康威尔生物化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In terms of Western medicine treatment: some first-line special drugs have a long treatment cycle, slow effect, and large side effects; some new drugs have unreasonable therapeutic efficacy, many restrictions, and low compliance with medication; surgical treatment of osteoporotic fractures has high risks and many complications , expensive and many other factors

Method used

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  • Medicine compound for treating osteoporosis and osteoporosis fracture
  • Medicine compound for treating osteoporosis and osteoporosis fracture
  • Medicine compound for treating osteoporosis and osteoporosis fracture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A medicine for treating osteoporosis and osteoporotic fractures, characterized in that it is prepared from the following raw materials in weight ratio: Drynaria: 30 grams, Dipsacus: 25 grams, Polygonum multiflorum: 15 grams, Tortoise shell: 22 grams, Epimedium: 20g, Wood Beetle: 9g, Natural Copper: 10g, Salvia: 20g, Safflower: 15g, Paeoniae Alba: 12g Clematis: 9g, Cnidium: 10g, chicken blood Vine: 12g, Angelica: 30g, Astragalus: 20g Yam: 22g, Poria: 12g, Rehmannia glutinosa: 20g, Antler gum: 15g, Dog spine: 15g Achyranthes bidentata: 12g, Eucommia: 10 Keel: 9 grams, Ligustrum lucidum: 15 grams, Psoraleae: 10 grams Atractylodes macrocephala: 12 grams, Melon seeds: 12 grams, Elderberry: 15 grams, Lycium barbarum: 15 grams, Qiannianjian: 10 grams sea octopus : 25g, Frankincense: 8g, Myrrh: 8g.

[0077] Preparation: According to the above formula, select high-quality pure natural Chinese medicinal materials, process them into medicinal powders according to conventional met...

Embodiment 2

[0080] Experimental Animals 32 BABC mice, half male and half female, clean grade, weighing 20-22 g, were provided by the Animal Center of Municipal People's Hospital. Divided into 4 groups at random, 8 in each group, namely blank control group 1, model control group 2, drug group 3 of the present invention, control drug group 4. Except for group 1 which was given normal saline, the rest of the groups were given dexamethasone 1 mg / kg, injected every three days, intramuscularly, and combined with retinoic acid, 70 mg / kg per day, for three weeks. Administration method During the modeling period, except that the blank control group and the model control group were given intragastric administration of equal volume of normal saline, the drug group of the present invention was administered by intragastric administration, and the dose was 0.5g / kg, three times a day. Linggubao capsule granules, the dose is 0.5g / kg, three times a day. Three weeks after administration, the number of tim...

Embodiment 3

[0084] clinical information

[0085] 227 patients with osteoporosis were selected from the cases in our hospital in recent years. The diseased sites were: 33 cases of cervical spine, 103 cases of lumbar spine, 51 cases of knee joint, 13 cases of ankle joint, and 27 cases of calcaneus. Randomly divided into a treatment group and a control group. The medical history, condition, age and gender of the selected cases in the treatment group and the control group were as similar as possible; the treatment group had 112 cases, aged 35-79 years; the control group had 115 cases, aged 38-80 years.

[0086] The treatment group took the medicine prepared in Example 1 of the present invention, 5 grams each time, 3 times a day, a course of treatment on 30 days, and took 2 courses of treatment continuously;

[0087] The control group received conventional drug Xianling Gubao Capsules (Guizhou Tongjitang Pharmaceutical Co., Ltd.). Take orally, 3 capsules each time, 2 times a day, divided into m...

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Abstract

The invention relates to a medicine compound for treating osteoporosis and osteoporosis fracture, which comprises the following components by weight: 30 g of rhizoma drynariae, 25 g of radices dipsaci, 15 g of radices polygoni multiflori, 22 g of turtleback, 20 g of herba epimedii, 9 g of woodlouse, 10 g of native copper, 20 g of red sage root, 15 g of safflower, 12 g of radices paeoniae alba, 9 g of radix clematidis, 10 g of fructus cnidii, 12 g of lignum millettiae, 30 g of angelica, 20 g of astragalus root, 22 g of Chinese yam, 12 g of tuckahoe, 20 g of prepared rhizome of rehmannia, 15 g of antler glue, 15 g of rhizoma cibotii, 12 g of achyranthes, 10 g of cortex eucommiae, 9 g of ossa draconis, 15 g of fructus ligustri lucidi, 10 g of fructus psoraleae, 12 g of atractylodes ovata, 12 g of semen melo, 15 g of elder, 15 g of medlar, 10 g of rhizoma homalonemae, 25 g of cuttle-bone, 8 g of frankincense, and 8 g of myrrh. The medicine compound is suitable for osteoporosis, low in cost, and remarkable in treatment effect, and has a board application prospect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating osteoporosis and osteoporotic fractures, also known as Huoxuebusui Shengguling Granules. Background technique [0002] Osteoporosis and osteoporotic fractures are important signs of an aging society. It is one of the most prominent social and medical problems in the world today, and has attracted widespread attention from the United Nations and countries around the world. Osteoporosis: refers to a systemic metabolic skeletal disease characterized by a decrease in the total amount of bone mass per unit volume (density) of normal mineralized bone and degeneration of bone tissue microstructure, resulting in increased bone fragility and a tendency to fracture; Osteoporotic fractures: Osteoporosis can lead to decreased bone mass and bone strength, and then fractures can occur under the influence of slight external force or other f...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P19/10A61K33/26A61K35/02A61K35/32A61K35/56A61K35/64A61K35/586A61K35/618
Inventor 吴淑玺
Owner 南通康威尔生物化工有限公司
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