Application of benzoazepine compounds in preparation of drugs for prevention or treatment of epilepsy

A benzoazepine and compound technology, applied in the field of drugs for preventing or treating epilepsy, can solve problems such as poor selectivity, and achieve the effects of preventing excessive activation, prolonging activation time, and highly specific
CN102895233AActive Publication Date: 2013-01-30SUZHOU UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2013-01-30

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Abstract

The present invention discloses an application of benzoazepine compounds, pharmaceutically acceptable salts or solvates thereof in preparation of drugs for prevention or treatment of epilepsy, wherein the benzazepine compound has the following general structural formula, an anti-epilepsy effect of the compounds is related to an allosterism activation sigma-1 receptor, and good treatment prospects of the compounds as full-novel anti-epilepsy drugs are showed.
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Description

technical field

[0001] The invention relates to a drug for preventing or treating epilepsy, in particular to a class of benzazepine compounds and pharmaceutically acceptable salts or solvates thereof, which are used as allosteric regulators of sigma-1 receptors in the preparation Application in drugs for the prevention or treatment of epilepsy. Background technique

[0002] Epilepsy is a common and serious disease of the central nervous system; its prevalence rate ranks third among nervous system diseases. There are approximately 50 million patients worldwide. The clinical manifestations of epilepsy patients are mainly unpredictable seizures. Its pathological basis is the excessive excitation of neurons. Regulating the excitability of neurons is one of the main methods of epilepsy treatment.

[0003] The currently marketed antiepileptic drugs mainly control convulsions: reduce the frequency of convulsions and shorten the duration of seizures. However, the entire patholo...

Claims

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