Preparation technology and production method for integrated new formulation of bighead atractylodes rhizome and monkshood decoction

Abstract

The present invention relates to a preparation technology and a production method for an integrated new formulation of a bighead atractylodes rhizome and monkshood decoction, wherein the raw materials of active ingredients comprise: 6 parts by weight of bighead atractylodes rhizome, 10 parts by weight of monkshood, 3 parts by weight of licorice, 4.5 parts by weight of ginger, and 6 parts by weight of Chinese-date. The production process of the integrated new formulation comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of bighead atractylodes rhizome and monkshood decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property, and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of bighead atractylodes rhizome and monkshood decoction can be realized simultaneously, and the medicament can be separately taken in four time slices according to the midnight-noon ebb-flow and qi and the blood flowing rule of a human body. The integrated new formulation of bighead atractylodes rhizome-monkshood decoction can be further prepared into films and transdermal agents, which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body, and can be directly absorbed through skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Baizhu Fuzi Decoction, and also relates to a preparation technology of a new integrated dosage form of Baizhu Fuzi Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxi...

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, dru