Microsphere separation and screening chip and preparation method thereof

A technology for separation and screening of microspheres, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., can solve problems such as high-precision separation and screening of microspheres with difficult target particle sizes

Active Publication Date: 2013-01-30
INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Separation using the principle of inertial microflow in a curved microfluidic channel is effective for the simple system separation of plasma and cells in blood, but it is difficult to achieve the target particle size for the separation of microspheres with a wide particle size distribution range. High-precision separation and screening

Method used

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  • Microsphere separation and screening chip and preparation method thereof
  • Microsphere separation and screening chip and preparation method thereof
  • Microsphere separation and screening chip and preparation method thereof

Examples

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Embodiment Construction

[0030] see figure 1 , figure 2 with image 3 As shown, the present invention provides a microsphere separation and screening chip, comprising:

[0031] A substrate 1, a liquid reservoir 2 is opened in the center of the substrate 1, and the material of the substrate 1 is a silicon wafer, a quartz wafer or PDMS;

[0032] A fluid channel 3, the fluid channel 3 is helical, it is prepared on the substrate 1, the fluid channel 3 has a liquid inlet 31 and a plurality of liquid outlets 32, the liquid inlet 31 and the liquid reservoir 2 Connected, the liquid outlet 32 ​​is located at the end of the helical fluid channel 3, the number of turns of the helical fluid channel 3 is greater than 3, the width of the fluid channel 3 is 50-500 microns, and the depth is 30-200 microns;

[0033] The filter column array 4, the filter column array 4 is prepared in the fluid channel 3, the filter column array 4 is arranged longitudinally in a row along the fluid channel 3, the column of the filte...

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Abstract

The invention discloses a microsphere separation and screening chip, comprising a substrate, wherein the center of the substrate is provided with a liquid storage tank; a fluid passage which is helical and is arranged on the substrate, wherein the fluid passage is provided with a liquid inlet and a plurality of liquid outlets, the liquid inlet is communicated with the liquid storage tank, and the liquid outlets are arranged at the tail end of the helical fluid passage; a filter column array arranged in the fluid, wherein the filter column array is orderly arranged vertically in rows along with the fluid passage; a cover plate arranged on the substrate, wherein the cover plate comprises a liquid filling port and a plurality of liquid outlets, the liquid outlets are communicated with the liquid storage tank, the liquid outlets are communicated with the liquid outlets of the fluid passage, and the cover plate is made from a quartz plate or PDMS. According to the invention, high precision separation of the microballoons within target particle size range can be realized, and simultaneously the characteristics of high reliability, low cost, etc. can be achieved.

Description

technical field [0001] The invention belongs to the field of microsphere screening, and in particular relates to a microsphere separation and screening chip and a preparation method thereof, which can be used for rapidly and accurately separating and screening tiny particles and a specific preparation method. Background technique [0002] Accurate separation and screening of tiny particles in a certain scale range is of great significance to many fields, such as biomedicine, environmental analysis, micro-nano processing, etc. The traditional separation method mainly uses the membrane separation method, which is limited by the pore size and uniformity of the membrane. When the particle size is less than tens of microns, the application of the membrane separation method is greatly restricted. [0003] With the rapid development of lab on a chip and microelectromechanical system (MEMS) technology in recent years, the accurate separation and screening of tiny particles on the ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 魏清泉俞育德周晓光李运涛韩伟静孙英男
Owner INST OF SEMICONDUCTORS - CHINESE ACAD OF SCI
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