Method for preparing 6-hydroxy caproic acid

A technology for hydroxycaproic acid and cyclohexene is applied in the field of catalytic oxidation to prepare 6-hydroxycaproic acid, which can solve problems such as single choice of raw materials, and achieve the effects of reducing economic risks, facilitating popularization and application, and being easy to operate.

Inactive Publication Date: 2013-02-13
CHINA TIANCHEN ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patents CN 101945847A and CN 1184804A all relate to a method for preparing 6-hydroxycaproic acid by o

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Add acetic acid and cyclohexene to the reactor;

[0029] (2) Add cyclohexanone and cobalt octanoate to the reactor;

[0030] (3) The mass ratio of cyclohexene to acetic acid is 0.4;

[0031] (4) The mass ratio of cyclohexanone to cyclohexene is 0.1%, and the mass ratio of cobalt octanoate to cyclohexene is 3%;

[0032] (5) Close the reaction kettle, turn on the stirring, and the stirring speed is 400r / min;

[0033] (6) Raise the temperature of the reactor to 110°C. Air is introduced, and the air flow rate is 50 liters / hour;

[0034] (7) The reaction time is 1.5 hours.

[0035] The conversion of cyclohexene was 20%, and the selectivity of 6-hydroxyhexanoic acid was 5%.

Embodiment 2

[0037] (1) Add acetic acid and cyclohexene to the reactor;

[0038] (2) Add cyclohexanone, cobalt chloride and manganese chloride to the reactor;

[0039] (3) The mass ratio of cyclohexene to acetic acid is 1;

[0040] (4) The mass ratio of cyclohexanone to cyclohexene is 2%, and the mass ratio of catalyst cobalt chloride and manganese chloride to cyclohexene is 1.5%;

[0041] (5) Close the reaction kettle, turn on the stirring, and the stirring speed is 350r / min;

[0042] (6) Raise the temperature of the reactor to 95°C. Air is introduced, and the flow rate of air is 45 liters / hour;

[0043] (7) The reaction time is 1.25 hours.

[0044] The cyclohexene conversion was 13%, and the selectivity to 6-hydroxyhexanoic acid was 10%.

Embodiment 3

[0046] (1) Add propionic acid and cyclohexene to the reactor;

[0047] (2) Add cyclohexanone and titanium silicon molecular sieve to the reactor;

[0048] (3) The mass ratio of cyclohexene to propionic acid is 2;

[0049] (4) The mass ratio of cyclohexanone to cyclohexene is 5%, and the mass ratio of titanium silicon molecular sieve to cyclohexene is 0.2%;

[0050] (5) Close the reaction kettle, turn on the stirring, and the stirring speed is 300r / min;

[0051] (6) Raise the temperature of the reactor to 80°C. Air is introduced, and the flow rate of air is 40 liters / hour;

[0052] (7) The reaction time is 1 hour.

[0053] The conversion of cyclohexene was 5%, and the selectivity of 6-hydroxyhexanoic acid was 15%.

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Abstract

The invention relates to a method for preparing 6-hydroxy caproic acid. The method uses cyclohexene to serve as a reaction raw material, air serves as an oxidizing agent, saturated fatty acid with the carbon number of 2-9 is selected to serve as a reaction solution of the reaction, and aldehyde or ketone is selected to serve as a reaction initiator. A catalytic agent can be soluble cobalt compounds, soluble manganese compounds and a soluble mixture of the cobalt compounds and the manganese compounds in a reaction medium, the catalytic agent can also be titanium silicalite molecular sieves. The method for preparing 6-hydroxy caproic acid selects a new reaction raw material-cyclohexene, expands roads for preparing the 6-hydroxy caproic acid and reduces economic risks on the industry caused by instable raw material cost. The method is simple and convenient to operate and simple to learn, used reaction equipment, reaction raw materials, the catalytic agent and the initiator are common and can be easily obtained, and the method is favorable for popularization and application.

Description

technical field [0001] The invention relates to a method for preparing 6-hydroxyhexanoic acid by catalytic oxidation using cyclohexene as a reaction raw material. Background technique [0002] Polycaprolactone is a synthetic polyester biopolymer material. It has good biocompatibility, good permeability and compatibility to steroid drugs, and has relatively satisfactory drug release behavior. Polycaprolactone will gradually lose weight in the body and become fragments, and finally be absorbed and excreted by the body without accumulating in the body. It can be used as a carrier material for drug release. Polycaprolactone is safe and non-toxic, and has good biodegradability and mechanical properties. It can adsorb the cells cultured in vitro to tissue engineering materials with good biocompatibility with the human body, carry out culture expansion, and implant the damaged parts to replace the damaged tissues. Polycaprolactone is not only widely used in the field of biomedic...

Claims

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Application Information

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IPC IPC(8): C07C59/01C07C51/31
Inventor 杨克俭马国栋张蒙史文涛耿玉侠钱震王志文张媛刘文王海国石华刘俊生左宜赞张舜光
Owner CHINA TIANCHEN ENG
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