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Method for separating and purifying monomeric compounds from ash bark

A technology for separation and purification of aurocetine, applied in the field of aurocetin, separation and purification of aurocetine, aurocetine A and aurocetine B, can solve the problems of single-component purification and inability to obtain multiple high-purity aurocetine components, and achieve saving Reagents, short process cycle and high efficiency

Inactive Publication Date: 2014-04-30
LIAOCHENG UNIV
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Problems solved by technology

[0004] The above-mentioned method or mainly carries out the extraction of the mixed coumarin of fenugreek bark, or carries out the purification of single component, can not obtain multiple high-purity bark bark coumarin components

Method used

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  • Method for separating and purifying monomeric compounds from ash bark
  • Method for separating and purifying monomeric compounds from ash bark

Examples

Experimental program
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Embodiment

[0021] Example: After crushing the medicinal material of Qinpi, put it into the reflux device system, use 85% ethanol as the extraction solvent, the liquid-solid ratio is 7, the medium temperature is 75°C, the extraction time for each reflux is 1 hour, and the reflux times are 3 times. After recovering the solvent from the extracting solution, the extract of the medicinal material Chrysanthemum chinensis is obtained.

[0022] Dissolve the crude powder of the medicinal material extract of Pittia chinensis with 30% methanol, and apply Superose 12 chromatography, and use methanol-water as the eluent for elution. 254 nm detection, collecting target component fractions, and concentrating the obtained fractions under reduced pressure to obtain the monomer compound to be separated.

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Abstract

The invention relates to a method for separating and purifying fraxetin, fraxin, aesculin and aesculetin from ash bark. The ash bark serves as a raw material and the method includes the steps of preparation of ash bark extract: performing reflux extraction on smashed ash bark crude drugs through ethanol or methanol, and obtaining extract coarse powder after the extract liquid is processed after the recovery of the solvent; and column chromatographic purification: taking Superose12 as a separating medium to perform chromatographic separation and purification, taking methanol-water or ethanol-water as the eluent to obtain high-purity monomeric compounds of fraxetin, fraxin, aesculin and aesculetin. The technical process is environment-friendly.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for separating and purifying fencetin, fencetrin, fencetrin A and fencetrin B from the traditional Chinese medicine fenperetin. Background technique [0002] Qinpi is the dry bark or bark of Fraxinus rhynchophylla Hance, Fraxinus chinensis Roxb., Fraxinus szaboana Lingelsh. or Fraxinus stylosa Lingelsh. of Oleaceae plants, bitter in nature and cold in taste. , has the effects of clearing heat and dampness, clearing liver and improving eyesight, relieving asthma and relieving cough. It is used for heat-toxin diarrhea, conjunctival congestion, swelling and pain, and nebula. The main active ingredients in tertiflorium are coumarins, which mainly include terperetin, terperetin, terperetin A and terperetin B. [0003] There are existing literature reports on methods for extracting and preparing coumarin components from Cortex chinensis. "Extraction method of co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/16C07H17/075C07H1/08
Inventor 白风沙柳仁民孙爱玲
Owner LIAOCHENG UNIV
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