Combined medical instrument formed by drug coated balloon and stent

A medical device and combined technology, applied in the field of medical devices, can solve the problems of long-term anticoagulant treatment, late thrombus, restenosis, etc., to avoid the formation of delayed thrombus, reduce restenosis, and avoid elastic retraction of blood vessels Effect

Inactive Publication Date: 2013-02-27
苏州爱瑞德医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, similar to PCI using DES in coronary heart disease, PCI and DES in the treatment of peripheral vascular stenosis also have problems such as restenosis, late thrombosis, and long-term anticoagulation, which make the treatment effect unsatisfactory.
[0008] Although drug-loaded balloon intervention can effectively reduce vascular intimal hyperplasia and avo...

Method used

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  • Combined medical instrument formed by drug coated balloon and stent
  • Combined medical instrument formed by drug coated balloon and stent
  • Combined medical instrument formed by drug coated balloon and stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Combination of single balloon loaded rapamycin with 316L stainless steel stent. Such as figure 1 As shown, a balloon 3 made of nylon 12 is connected to one end of the manufactured balloon catheter 2 with the catheter adapter 1, and before the balloon is crimped and crimped, the balloon is soaked in rapamycin - In the poloxamer ethanol solution, the drug is deposited on the surface of the balloon, taken out and dried, and then immersed in the solution again, and the balloon is loaded with 5 μg / mm repeatedly. 2 rapamycin-poloxamer coating 4, the balloon was rolled up after vacuum drying, and then a 316L stainless steel stent 5 was pressed and held on the balloon to obtain a single balloon loaded with rapamycin and 316L stainless steel stent combination medical device can be used for PTCA surgery;

Embodiment 2

[0064] Single-balloon-loaded paclitaxel in combination with an L605 cobalt-chromium stent. Such as figure 1As shown, a balloon 3 made of polyetheramide is connected to one end of the manufactured balloon catheter 2 with the catheter adapter 1, and before the balloon is crimped and gripped, ultrasonic spraying Spray the paclitaxel-poloxamer ethanol solution, and repeatedly load the balloon with 5 μg / mm 2 paclitaxel-poloxamer coating 4, the balloon was rolled after vacuum drying, and then a L605 cobalt-chromium alloy stent 5 was pressed and held on the balloon to obtain a single balloon-loaded paclitaxel and L605 cobalt-chromium alloy A medical device combined with a stent, which can be used in PTCA surgery;

Embodiment 3

[0066] Single balloon-loaded Erolimus in combination with a platinum-chromium alloy stent. Such as figure 1 As shown, a balloon 3 made of polyetheramide is connected to one end of the manufactured balloon catheter 2 with catheter adapter 1, and the balloon is soaked in rapamycin before the balloon is crimped In the acetonitrile solution of the hormone derivatives Erolimus and Poloxamer, the drug is deposited on the surface of the balloon, taken out and dried, and then immersed in the solution again, and the balloon is loaded with 6 μg / mm repeatedly. 2 The Erolimus-poloxamer coating 4 is vacuum-dried and the balloon is rolled up, and then a platinum-chromium alloy stent 5 is pressed on the balloon to obtain a single balloon-loaded Erolimus Medical devices combined with platinum-chromium alloy stents can be used in PTCA surgery;

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Abstract

The invention discloses a combined medical instrument formed by a drug coated balloon and a stent. The combined medical instrument comprises the balloon and the stent, a drug-containing coating is coated outside the balloon, the stent is pressed on the outer wall of the balloon in a held manner, a conduit communicated with the balloon is arranged at one end of the balloon, and the far end of the conduit is connected with a conduit base. By the structure, the novel medical instrument is formed by the drug coated balloon (DCB) carrying drugs and the bare metal stent (BMS), so that the therapeutic effect of low restenosis, similar to that of a drug eluting stent (DES), is achieved through a series of novel design of the balloon and the BMS; meanwhile, late stent thrombosis possibly appearing after the DES is used, the risks brought about by taking anticoagulants for a long period of time, and the financial burden caused by taking the anticoagulants can be avoided; and the novel instrument can be used in a way similar to that of the existing DES, so that the same convenience is achieved.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a combined medical device containing a drug-loaded balloon and a coronary stent, which is used to treat myocardial ischemic heart disease caused by coronary atherosclerosis and peripheral vascular stenosis. disease. Background technique [0002] Coronary atherosclerotic heart disease (referred to as coronary heart disease, CHD) is a heart disease caused by atherosclerotic lesions in the coronary arteries resulting in narrowing or blockage of the coronary arteries. It is a relatively common disease among cardiovascular and cerebrovascular diseases. Statistics It shows that more than 40% of the deaths in China in 2010 were due to cardiovascular diseases, which accounted for the first among all causes of death. According to the data of the World Health Organization in 2011, the number of deaths from coronary heart disease in China ranks second in the world. Current treatments for co...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61M31/00
Inventor 张弢王捷冯海全唐烈
Owner 苏州爱瑞德医疗科技有限公司
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