Application of Houttuynoid C for preparing medicine for treating acute gout
A technology for acute gout and medicine, which is applied in the application field of Houttuynoid C in the preparation of medicines for the treatment of acute gout, which can solve problems such as aplastic anemia and neutropenia, and achieve the effect of strong prevention and treatment activity and outstanding substantive characteristics
Inactive Publication Date: 2013-03-27
何晓涛
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Problems solved by technology
Although they have fast anti-inflammatory and analgesic effects, their toxic and side effects are also quite obvious. For example, the effective dose of colchicine is similar to the dose that produces diarrhea and other gastrointestinal symptoms. Absolutely contraindicated in the case of bleeding, and the administration of phenylbutazone for as short as 3 weeks can also cause severe neutropenia or aplastic anemia
Method used
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Experimental program
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Effect test
Embodiment 1
[0016] Embodiment 1: the preparation of compound Houttuynoid C tablet involved in the present invention:
[0017] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0018] Embodiment 2: the preparation of compound Houttuynoid C capsule of the present invention:
[0019] Get 20 grams of compound Houttuynoid C, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0020] The following pharmacodynamic experiments will further illustrate its drug activity.
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The invention provides novel application of Houttuynoid C in the medical science, in particular application of Houttuynoid C for preparing a medicine for treating acute gout. The experimental research result shows that Houttuynoid C has the effect of protecting an acute gout model of human vascular endothelial cell damage caused by urate and can inhibit expression of ICAM-1, therefore, Houttuynoid C can be used for preparing the medicine for treating acute gouty inflammation. The application of Houttuynoid C for preparing the medicine for treating acute gout is disclosed for the first time; because the skeleton type belongs to a brand new skeleton type and the activity of Houttuynoid C for preventing and treating acute gout is strong unexpectedly, the possibility that other compounds give any inspiration does not exist; Houttuynoid C has outstanding substantive characteristics; and simultaneously, Houttuynoid C has obvious progress for preventing and treating acute gout.
Description
technical field [0001] The present invention relates to the new application of Houttuynoid C in medicine, in particular to the application of Houttuynoid C in preparing medicine for treating acute gout. Background technique [0002] Gout, also known as gouty arthritis, is a disease caused by the disorder of purine metabolism in the body. It is manifested by excessive uric acid in the blood, and it is easy to cause urate (MSU) to crystallize in joints and other tissues. The acute attack of gout is due to the local neutrophil infiltration and inflammatory response caused by MSU deposited in the joints. [0003] Western medicine selects three kinds of medicines for use in the acute attack stage of gout: colchicine, non-steroidal anti-inflammatory drugs and corticosteroids. The mechanism of action of colchicine is to bind to the tubulin of neutrophils, thereby hindering the activity of granulocytes and inhibiting granulocyte infiltration. Non-steroidal anti-inflammatory drugs ...
Claims
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Login to View More IPC IPC(8): A61K31/7048A61P19/06A61P29/00
Inventor 何晓涛
Owner 何晓涛