Yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof

A technology of compound preparations for chronic kidney disease, applied in the field of compound preparations of traditional Chinese medicine for warming yang and promoting blood circulation, can solve problems such as difficult to control, long formation time of glomerulosclerosis, etc., and achieve the effect of delaying progress, easy to popularize and use, and less medicinal taste

Inactive Publication Date: 2013-05-08
SHANGHAI PUTUO DISTRICT CENT HOSPITAL +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although the current model induced by Staphylococcal Enterotoxin B (Staphylococcal Enterotoxin B, SEB) or SEB is close to the pathogenesis of human IgAN, reflecting some of its pathological changes, the shortcoming of this model is glomerulosclerosis. Formation time is long and difficult to control

Method used

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  • Yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof
  • Yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof
  • Yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: A clinical study on the improvement of CKD by the compound preparation of Wenyang Huoxue traditional Chinese medicine (Wenyang Huoxue prescription) used for the prevention and treatment of chronic kidney disease.

[0055] By using Wenyang Huoxue Decoction to treat CKD2-3 patients with yang deficiency and blood stasis type, observe its effect on renal function: including serum creatinine (serum Scr), serum cystatin C (Cys-C), blood urea nitrogen (BUN), 24 Hourly protein quantification, endogenous creatinine clearance rate (Ccr), glomerular filtration (eGFR), etc. Blood routine: including hemoglobin (Hb), red blood cells (RBC), white blood cells (WBC), platelets (PLT), etc., liver function : Including alanine aminotransferase (ALT), aspartate aminotransferase (AST), etc., electrocardiogram (EKG) and other experimental indicators, aiming to further understand the clinical efficacy and efficacy of Wenyang Huoxue Fang in the treatment of CKD stage 2-3 patients with...

Embodiment 2

[0229] Example 2: Effect of Wenyang Huoxue Decoction on renal function in rats with renal failure.

[0230] To observe the effect of Wenyang Huoxue Decoction on renal function in rats with 5 / 6 nephrectomy for chronic renal failure, and explore its possible mechanism of delaying the progression of the disease.

[0231] 120 SD male rats were randomly divided into sham operation group (group A), model group (group B), Wenyang Huoxue prescription group (group C), Kesu subgroup (group D) and Wenyang Huoxue recipe + Ke prime subgroup (group E).

[0232] Model group: A rat model of chronic renal failure was made by 5 / 6 nephrectomy. SD male rats were fed adaptively, and 2 / 3 of the left nephrectomy was performed at the fifth week. After anesthesia, they were fixed on the operating table in a prone position, routinely disinfected in the back operation area, spread a drape, and made a straight incision on the left side of the back Separate the skin, separate the psoas muscle, enter the...

Embodiment 3

[0247] Example 3: Research on the mechanism of Wenyang Huoxue Decoction in preventing and treating chronic aristolochic acid nephropathy.

[0248] In view of the current lack of understanding of the pathogenesis of Aristolochia nephropathy and the lack of treatment, the present invention can provide a new treatment method for Aristolochia nephropathy through Wenyang Huoxue prescription, which can better improve the current treatment of Aristolochia nephropathy. Current status of research on therapeutic efficacy.

[0249] This embodiment includes two parts: in vivo experiment and in vitro experiment.

[0250] Among them, the purpose of the in vivo experiment is to study the mechanism of renal ischemic injury in rats with chronic aristolochic acid nephropathy, analyze the possible relationship between renal microvascular changes and renal tubular injury, apoptosis and interstitial fibrosis; study Ang-1, Ang- 2. The expressions of Tie-2, VEGF, BMP-7, Caspase-3, and CD34 in rat k...

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Abstract

The invention discloses a yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof. Raw materials of the traditional Chinese compound preparation comprise the components: 15-30g of cistanche, 15-30g of herba epimedii, 10-15g of peach kernel, 10-15g of flowers carthami and 10-15g of moutan bark. In use, the traditional Chinese compound preparation is decocted with water. The invention further provides the application of the traditional Chinese compound preparation for preventing and treating chronic kidney diseases, namely, the traditional Chinese compound preparation can be used for researching pathogenesis of aristolochzc acid nephropathy and use for interferring a rat model with IgAN glomerular sclerosis. According to the yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases provided by the invention, aiming at the deficiencies in treatment of chronic kidney diseases at present, a novel treating and researching method for chronic kidney diseases is provided, so that the current research status for curative effect in treatment of chronic kidney diseases can be better improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription and its application, in particular to a Chinese medicine compound preparation for warming yang and promoting blood circulation and its application for preventing and treating chronic kidney disease. Background technique [0002] Chronic kidney disease (CKD) is a common clinicopathological process of various kidney diseases except acute nephritis and acute urinary tract infection (acute inflammatory disease of the kidney). (End stage renal disease, ESRD). The United States kidney disease data show that the incidence of end-stage renal disease is increasing, from 1998 to 2002 from 39.4 people / million to 98.3 people / million. Based on this estimate, the data will increase by 4.1% per year in the next 10 years. In my country, the overall prevalence of CKD in the adult population has reached 10.8%. Therefore, how to prevent and treat CKD at an early stage and delay the progression of the...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P13/12
Inventor 彭文何立群王云满王浩王利付文成池杨峰
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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