Drainage-type preparation chromatographic column

Abstract

The invention discloses a drainage-type preparation chromatographic column. The drainage-type preparation chromatographic column realizes accurate chromatographic separation in a complex environment with two different mediums comprising a viscous fluid and a pipe inner-wall filler. The drainage-type preparation chromatographic column comprises a chromatographic column body, an upper top cover flange, a column body upper flange, a drainage hole, a feeding inlet, a discharge outlet, an outlet pipe, a column body lower flange and a bottom outlet flange. The drainage hole is arranged on the chromatographic column body. A distribution plate and a uniform distribution device are arranged between the upper top cover flange and the column body upper flange. A distribution plate and a uniform distribution device are arranged between the column body lower flange and the bottom outlet flange. The drainage-type preparation chromatographic column can solve the problem of incomplete separation of a boundary layer fluid, can lead out the impure fluid, can improve chromatographic column separation purity, is optimized from the point of fluid machinery, reduces a cost, reduces manpower and material resources, shortens a design period and can be processed easily on a tool.

Description

technical field [0001] The invention relates to a preparative chromatographic column in analytical chemical equipment, in particular to a drainage type preparative chromatographic column. Background technique [0002] In the past ten years, chromatographic separation has developed from the analysis scale to the preparation scale and production scale in practice. High-efficiency preparative chromatography has been used in the preparation of high-purity substances such as the pharmaceutical industry, bioengineering, and natural product separation and purification, and has become the research frontier of high-efficiency separation and purification technology. [0003] Preparative chromatographic columns are the key equipment for preparative liquid chromatography separation. In order to meet the needs of preparative production, some large preparative chromatographic columns have been developed. Consult related documents, Chinese Patent Gazette, publication number is CN 10143377...

AI Technical Summary

Problems solved by technology

With the increase of the overall size of the prepared chromatographic column, the influence of the filler on the fluid resistance and the influence of the smooth column wall on the fluid, it is difficult to ensure that the same separated substance reaches the same cross-section uniformly and at the same speed at the same time, resulting in different band flow patterns. Uniformity, eventually causing a decline in the separation effect

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