Terbinafine hydrochloride cream and preparation method thereof

A technology of terbinafine hydrochloride and nafine cream, which is applied in the direction of ointment delivery, emulsion delivery, skin diseases, etc., and can solve the problems of large skin irritation, unstable milk droplets, and non-moisturizing cream, and reach the skin Less irritating, the main ingredients are mixed evenly, and the effect of cream moisturizing
CN103126976BActive Publication Date: 2015-05-20TIANSHENG PHARMA GROUP

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
TIANSHENG PHARMA GROUP
Publication Date
2015-05-20

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Abstract

The invention relates to a terbinafine hydrochloride cream. According to the invention, terbinafine hydrochloride with an effective amount is adopted as a main raw material, and the cream is prepared with the main raw material and pharmaceutically acceptable auxiliary materials of sodium dodecyl sulfate, propylene glycol, glycerol monostearate, octadecanol, white vaseline, light liquid paraffin, ethyl paraben, and water. The cream provided by the invention has the advantages of moisturizing cream body, good spreadability, convenient medication, low irritation to skins, good treatment effect, and stable quality.
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Description

technical field

[0001] The invention relates to a cream for treating superficial mycosis of the skin, in particular to a terbinafine hydrochloride cream and a preparation method thereof. Background technique

[0002] Due to the wide application of antibiotics and the change of body immunity, there are more and more diseases caused by fungal infections. Since the first antifungal antibiotic amphotericin came out in 1955, the diagnosis of fungal diseases has become more and more perfect. The research and development of fungal drugs has also made great progress. At present, there are more than 80 kinds of antifungal drugs used clinically in the world.

[0003] Among them, terbinafine hydrochloride is an allylamine derivative and has broad-spectrum antifungal activity. It mainly inhibits fungal squalene cyclooxygenase, causing ergosterol deficiency and interfering with cell membrane integrity, so that fungi stop growing and play an antibacterial role; at the same time, squalene...

Claims

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