Terbinafine hydrochloride cream and preparation method thereof
A technology of terbinafine hydrochloride and nafine cream, which is applied in the direction of ointment delivery, emulsion delivery, skin diseases, etc., and can solve the problems of large skin irritation, unstable milk droplets, and non-moisturizing cream, and reach the skin Less irritating, the main ingredients are mixed evenly, and the effect of cream moisturizing
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Embodiment 1
[0035] A kind of terbinafine hydrochloride emulsifiable paste, the quality proportioning relation that its each material is formed is:
[0036] Terbinafine Hydrochloride 2g, Sodium Lauryl Sulfate 2g,
[0037] Propylene Glycol 20g, Glyceryl Monostearate 12g,
[0038] Stearyl alcohol 10g, white petrolatum 10g,
[0039] Ethylparaben 0.4g, light liquid paraffin 14g,
[0040] 130g of water;
[0041]Its preparation method, it is to carry out according to the steps described below: take 8g propylene glycol and terbinafine hydrochloride mix, 50 ℃ slightly heat to dissolve, set aside; Take another 2g propylene glycol and ethylparaben to mix, 50 ℃ slightly heat to dissolve , for subsequent use; take the remaining 10g propylene glycol, sodium lauryl sulfate, water, and the mixed solution of propylene glycol and ethylparaben, and mix them in a container to form an aqueous phase; in addition, add glyceryl monostearate , stearyl alcohol, white petrolatum and light liquid paraffin in a w...
Embodiment 2-4
[0076] Using the same preparation method as in Example 1, according to the material composition ratio described in the following table 6, prepare terbinafine hydrochloride emulsifiable paste containing terbinafine hydrochloride specification of about 1%. Terbinafine hydrochloride cream for comparison:
[0077] Table 6
[0078] Name of raw material
Example 2
Example 3
Example 4
Example 1
Terbinafine hydrochloride (g)
2
2
2
2
2
3
3
2
Propylene glycol (g)
20
20
20
20
water (g)
120
140
122
130
15
11
15
12
Octadecanol (g)
15
5
12
10
White petrolatum (g)
12
5
12
10
14
14
14
14
Ethylparaben (g)
0.4
0.4
0.4
0.4
[0079] For the terbinafine hydrochloride emulsifiable paste o...
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Abstract
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