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Tablet pharmaceutical composition containing neutral phosphate

A composition, technology of phosphoric acid, applied in the field of medicine

Active Publication Date: 2013-06-05
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned properties of the metal ion salt of phosphoric acid make this drug encounter challenges when preparing solid preparations, especially tablets, especially when preparing tablets with good disintegration properties and / or stability properties

Method used

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  • Tablet pharmaceutical composition containing neutral phosphate
  • Tablet pharmaceutical composition containing neutral phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] prescription:

[0127] Element

Quantity (mg / tablet)

Disodium phosphate

852

Potassium dihydrogen phosphate

155

Sodium dihydrogen phosphate

130

Sodium carboxymethyl starch

51.6

Polyvinylpyrrolidone

38.8

steviol glycoside

13

Talc powder

51.6

[0128] Preparation:

[0129] Each material is crushed separately;

[0130] Weigh three kinds of phosphates, sodium carboxymethyl starch, and steviol glycoside according to the prescription amount, and mix the weighed powders evenly;

[0131] The polyvinylpyrrolidone (being PVP K30) of weighing recipe quantity, in the following examples, if not otherwise specified, all is to use PVP K30. In one embodiment of any aspect of the present invention, described polyvinylpyrrolidone is PVP K30), 90% ethanol is mixed with 3% solution;

[0132] 3% PVP solution is used as a binder, and the mixed material is made into wet granules;

[0133...

Embodiment 2

[0137] prescription:

[0138] Element

[0139] Disodium phosphate

[0140] Preparation: Carry out with reference to the method of Example 1, use 80% ethanol to prepare adhesive, obtain the composition of the present invention (can be recorded as R2).

Embodiment 3

[0142] prescription:

[0143] Element

[0144] Preparation: Carry out with reference to the method of Example 1, use 98% ethanol to prepare adhesive, obtain composition of the present invention (can be recorded as R3).

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PUM

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Abstract

The invention relates to a tablet pharmaceutical composition containing neutral phosphate, which comprises phosphoric acid metal ion salt, polyvinylpyrrolidone, sodium carboxymethyl starch, talcum powder and optional flavoring agent. The tablet pharmaceutical composition can be tablets, and the tablets present neutrality and can be used for supplementing phosphorus for human body so that the balance of phosphorus in human body can be maintained. The tablet pharmaceutical composition has good pharmacy performance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a composition, which contains phosphate, and the specific salts are potassium phosphate and sodium phosphate, and the composition of the invention is specifically a tablet, and the tablet is generally It is neutral and can be used to supplement phosphorus in the human body to maintain the balance of phosphorus in the human body. Background technique [0002] Phosphorus is an essential mineral nutrient for the human body. Phosphorus accounts for one quarter of the mineral mass in the human body, or one percent of the body weight. An adult weighing 70 kg has about 560 to 850 grams of phosphorus in the body, which also means that phosphorus accounts for 2%-4% of the dry weight of the cells. Among them, 85% are combined with calcium in the state of inorganic salts, forming insoluble apatite in bones and teeth; 1% are in blood and body fluids, and the remaining 14% are in software ti...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K47/36A61K9/20A61P3/12
Inventor 徐风华郭荣荣陈迁
Owner GENERAL HOSPITAL OF PLA
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