Application of targeted beta amyloid protein photographic developer
A technology of amyloid protein and imaging agent, applied in the field of imaging agent, can solve the problems of heavy economic burden and achieve the effect of strong binding ability
Inactive Publication Date: 2013-06-05
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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Problems solved by technology
According to the survey of the US Department of Health and Human Services, in 2012 and 2013, the Treasury Department will reach an incredible figure of 130 million US dollars for AD treatment research, which is more than 25% more than the current annual budget for Alzheimer's research. a heavy economic burden on society
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[0035] (1) Synthesis of Oleic Acid Modified Magnetic Iron Tetroxide (SPIO) Nanoparticles
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Abstract
The invention discloses application of a targeted beta amyloid protein photographic developer in diagnosis of an alzheimer disease. The targeted beta amyloid protein photographic developer comprises (1-{6-[(monoethyl succinate radical) (methyl) amino]-2-naphthyl}ethidene) malononitrile modificative magnetic nanoparticles. The targeted beta amyloid protein photographic developer and a tangle A beta (1-40) have strong combining capacity, so that the targeted beta amyloid protein photographic developer can peculiarly identify age pigment. By combining magnatic resonance imaging (MRI) inspection, beta amyloid protein can be peculiarly displayed, and accordingly targeted early detection of the alzheimer disease (AD) is achieved.
Description
technical field [0001] The invention belongs to the field of imaging agents, and in particular relates to the application of an imaging agent targeting beta amyloid protein. Background technique [0002] Alzheimer's disease (AD) is a disease named after the German psychiatrist Alois Alzheimer. It is a degenerative brain nervous system disease and the main type of senile dementia. The main clinical manifestations are the gradual loss of memory and the weakening of time and space orientation , loss of self-care ability, indifferent and withdrawn personality, and cognitive dysfunction, etc., advanced patients may be life-threatening [1-5] , have a serious impact on the quality of life and physical and mental health of the elderly. With the development of science and social progress, people's living standards have improved, and living conditions have also been greatly improved. Medical technology has continued to develop and progress, resulting in the extension of the average l...
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Inventor 张冬法焕宝周静婷文利
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV