Antimicrobial formulations that aid in wound healing

Abstract

The invention discloses compositions and formulations for the treatment of clean or infected wounds, some of the inventive formulations can be used to reduce or eliminate microbial contamination from surfaces such as skin, and inanimate objects such as countertops, cooking utensils, medical devices, cookware, food, grooming aids and agricultural biocides, and the like. Some of these compositions and formulations are well suited for use in wound dressings. Some of the formulation can kill and / or inhibit the growth of pathogenic bacteria, fungi, spores and viruses. The formulations comprise a compound such as an osmoticum in high enough concentration to create an osmotic gradient and at least one compound that acts to comprise the integrity of a microorganism's membrane or cell wall. These formulations may optimally include at least one agent that thickens the formulations. In some aspects the formulation is in the form of an emulsion.

Description

[0001] priority [0002] This application claims priority to US Provisional Patent Application No. 61 / 391 / 710, filed October 11, 2010, which is hereby incorporated by reference in its entirety. technical field [0003] Some aspects of the invention relate to general antimicrobial compositions focused on wound management. Background technique [0004] Wound healing is a tissue regeneration process that restores the function of a skin defect. However, wound infection halts this repair process by prolonging the inflammatory phase, preventing progression to proliferation and remodeling. The result is longer healing times, increased patient discomfort, reduced quality of life, disfigurement of scar formation, and potentially increased mortality. Current methods of managing wound-level infections rely on antibiotics or potentially cytotoxic antimicrobials such as silver or iodine. However, worldwide growth of antibiotic-resistant bacterial strains such as methicillin-resistant ...

AI Technical Summary

Problems solved by technology

However, worldwide growth of antibiotic-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus (MRSA) has begun to reduce the availability of antibiotics

Alternatively, antimicrobial agents (eg, silver and iodine) have been shown to impair the coordinated process of wound healing, leading to greater scar formation and delayed wound closure

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