Method for removing gamma rays generated during Cerenkov fluorescence imaging

Abstract

The invention discloses a method for removing gamma rays generated during Cerenkov fluorescence imaging. The method mainly solves the problem that the quality of images is interfered by gamma rays generated during Cerenkov fluorescence imaging. The method includes steps of (1), acquiring image data; (2), preprocessing an image; (3), computing the width of a mask of the image according to a following formula; (4), acquiring a local variance image; (5), determining interfered pixels; (6), constructing a signal judging matrix; (7), repairing the interfered pixels and acquiring a preliminarily repaired image; (8), judging whether the preliminarily repaired image meets processing requirements or not; and (9), suppressing noise of the preliminarily repaired image. The method has the advantages that the gamma rays in the Cerenkov fluorescence image can be basically completely eliminated, Cerenkov fluorescence signals in the image can be kept to the greatest extent, and the quality of the image formed by means of Cerenkov fluorescence imaging is improved.

Description

technical field [0001] The invention relates to the technical field of image processing, and further relates to a method for removing interference in Cerenkov fluorescence imaging in the field of medical image processing. The invention can be used to remove gamma ray interference existing in the Cerenkov fluorescence imaging process and improve the image quality of the Cerenkov fluorescence imaging. Background technique [0002] In Cerenkov fluorescence imaging, it is hoped that the fluorescent signal in the imaging image can accurately correspond to the activity of the radionuclide, so as to reflect the proliferation and apoptosis of the target cells labeled with the radionuclide. However, due to the generation of Cherenkov light, accompanied by positron annihilation or γ-decay, the signal is faced with the problem of γ-ray interference. It is hoped that the signal can be preserved as much as possible while removing the γ-ray interference. [0003] Due to the particularity...

AI Technical Summary

Problems solved by technology

The shortcoming of this patent application is that it does not consider how to deal with the interference of gamma rays on Cerenkov imaging when collecting planar optical images

There are two disadvantages of this method. One is that the processing results of different cameras are different, and the processing results depend on the performance of the camera processing module.

The second is that the interference of γ-rays cannot be completely removed, especially under the condition of low radioactive activity (less than 10uCi on the equivalent surface), the quality of image processing will decrease instead.

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