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Method for measuring content of o/m-toluene sulphonamide in saccharin sodium by gas chromatography-mass spectrometry

A technology of toluenesulfonamide and gas chromatography-mass spectrometry, which is applied in the field of detection, can solve problems such as affecting analysis results, and achieve the effect of improving accuracy

Inactive Publication Date: 2013-07-03
CHINA NAT ACAD NANOTECH & ENG
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Problems solved by technology

[0002] As a food additive, sodium saccharin is mainly analyzed by gas chromatography at home and abroad for the content of o- and p-toluenesulfonamide, and the limitation of gas chromatography analysis is: when detecting the content of o- and p-toluenesulfonamide in , it may be covered by chromatographic peaks of other impurities during analysis, thus affecting the analysis results

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  • Method for measuring content of o/m-toluene sulphonamide in saccharin sodium by gas chromatography-mass spectrometry
  • Method for measuring content of o/m-toluene sulphonamide in saccharin sodium by gas chromatography-mass spectrometry
  • Method for measuring content of o/m-toluene sulphonamide in saccharin sodium by gas chromatography-mass spectrometry

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Embodiment

[0049] Embodiment: a kind of method for measuring the content of o-toluenesulfonamide in sodium saccharin by gas chromatography-mass spectrometry, is characterized in that it comprises the following steps:

[0050] 1) Preparation of internal standard solution: the internal standard is caffeine, dissolve 25mg of caffeine in dichloromethane, and set the volume to 100mL volumetric flask;

[0051] 2) Preparation of detection solution: Weigh 10.0g of sodium saccharin sample into a 100mL beaker, add 20mL of water, and measure its pH value. If the pH value is not within the range of 7-8, use 1mol / L NaOH or 1mol / L HCl Adjust the pH of the solution to 7-8;

[0052] Transfer the solution into a 250mL separatory funnel, add 50mL of dichloromethane, oscillate several times, and let it stand for 10 minutes; collect the lower clear liquid, repeatedly extract the sodium saccharin solution with 50mL of dichloromethane, concentrate each extract, and then use Anhydrous Na 2 SO 4 Remove the m...

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Abstract

The invention discloses a method for measuring the content of o / m-toluene sulphonamide in saccharin sodium by gas chromatography-mass spectrometry. The method is characterized by comprising the following steps of: 1) preparation for internal standard solution; 2) preparation for detection solution; 3) preparation for reference solution; 4) quantitative determination; and 5) result calculation. The method disclosed by the invention has the advantage of being capable of effectively improving the accuracy of analytical test compared with the prior art.

Description

(1) Technical field: [0001] The invention relates to a detection method, in particular to a detection method for determining the content of o- and p-toluenesulfonamide in sugar clear sodium by gas chromatography. (two) background technology: [0002] As a food additive, sodium saccharin is mainly analyzed by gas chromatography at home and abroad for the content of o- and p-toluenesulfonamide, and the limitation of gas chromatography analysis is: when detecting the content of o- and p-toluenesulfonamide in , it may be covered by chromatographic peaks of other impurities during analysis, thereby affecting the analysis results. (3) Contents of the invention: [0003] The object of the present invention is to provide a kind of method for measuring o-toluenesulfonamide content in sodium saccharin by gas chromatography, which can solve the deficiencies in the prior art to improve the accuracy of analysis and inspection. [0004] Technical scheme of the present invention: a kind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 胡彩花牛轻轻周晨光李凤新
Owner CHINA NAT ACAD NANOTECH & ENG
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