Citicoline sodium tablet and preparation method thereof
A technology of citicoline sodium and coated tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve problems such as tablet instability and achieve quality control , Guarantee the quality of medicines and the effect of high product quality standards
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Embodiment 1
[0035] Embodiment 1, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:
[0036]
[0037] Coating Solution Prescription:
[0038] Hydroxypropyl Methyl Cellulose: Cellulose Acetate Phthalate 1:2 160g
[0039] 55% ethanol 800ml
[0040] The preparation method of above-mentioned citicoline sodium tablet is as follows:
[0041] (1) Mix 20g of the main ingredient with 20g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;
[0042] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,
[0043] (3) Add 10% starch slurry, mix well to make soft material,
[0044] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;
[0045] (5) Add magnesium stearate and mix evenly, tabletting, inspection;
[0046] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add ethanol to disperse;
[...
Embodiment 2
[0049] Embodiment 2, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:
[0050]
[0051] Coating Solution Prescription:
[0052] Hydroxypropyl methylcellulose: polyvinyl acetal diethylamine acetic acid 1:1 170 parts
[0053] 900 parts of 60% ethanol.
[0054] The preparation method of above-mentioned citicoline sodium tablet is as follows:
[0055] (1) Mix 25g of the main ingredient with 25g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;
[0056] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,
[0057] (3) Add 10% starch slurry, mix well to make soft material,
[0058] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;
[0059] (5) Add magnesium stearate and mix evenly, tabletting, inspection;
[0060] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add...
Embodiment 3
[0062] Embodiment 3, a kind of citicoline sodium tablet, the composition of every 1000 is as follows:
[0063]
[0064] Coating Solution Prescription:
[0065] Hydroxypropyl Methyl Cellulose:Ethyl Cellulose 2:1 180 parts
[0066] 60% ethanol 1000 parts.
[0067] The preparation method of above-mentioned citicoline sodium tablet is as follows:
[0068] (1) Mix 30g of the main ingredient with 30g of lactose, add the rest of the main ingredient, mix evenly, and grind through an 80-mesh sieve;
[0069] (2) Add starch and sodium carboxymethyl starch respectively and mix well, pass through 80 mesh sieve twice,
[0070] (3) Add 10% starch slurry, mix well to make soft material,
[0071] (4) 20 mesh sieves are granulated, 60 DEG C are dried, and 16 mesh sieves are granulated;
[0072] (5) Add magnesium stearate and mix evenly, tabletting, inspection;
[0073] (6) The preparation of coating liquid, take stomach-dissolving type coating powder and add ethanol to disperse;
[00...
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