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Traditional Chinese medicine composition and preparation method thereof

A technology of composition and natural medicine, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve the problems of dehydration, acid-base balance imbalance, malnutrition and other problems of patients, and achieve increased inhibition, enhanced inhibition, and good synergy The effect of action

Inactive Publication Date: 2013-07-10
张宗升
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Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Traditional Chinese medicine composition and preparation method thereof
  • Traditional Chinese medicine composition and preparation method thereof

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Effect test

Embodiment approach

[0034] The first step: preparation of various extracts

[0035] (1) Preparation of the concentrated extract of Andrographis paniculata decocted in water

[0036] According to the compatibility ratio of 1:1 or 1-6:1, take Andrographis paniculata and Piper longum, soak in 10 times the amount of distilled water, soak for 1 hour, heat and decoct on the electric stove with asbestos net for 1 hour, filter with silk cloth, save the filtrate and medicinal residue Add 6 times more distilled water, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate to a small volume, filter with an ultrafiltration membrane, and dry under reduced pressure at 70°C for 36 hours in a vacuum drying oven to obtain a brown-yellow powder.

[0037] (2) preparation of andrographolide

[0038] Weigh an appropriate amount of Andrographis paniculata powder, pre-treat with enzymatic hydrolysis, soak in ethanol, filter, and recover ethanol to obtain extract, wash with petroleum ethe...

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Abstract

The invention relates to a natural pharmaceutical composition, a preparation method thereof and application thereof in preparation of toxicity reducing and efficacy enhancing drugs for cancer chemotherapy. The natural pharmaceutical composition consists of a decoction concentrated extract of andrographis paniculata (Burm.f.) Nees and piper longum I., andrographolide, an ethanol extract of piper longum I. and piperine which are in the ratio of (2-3):(6-9):(5-8):(1-5). The composition has an excellent treatment effect on cancer-chemotherapy-related diarrhea and can simultaneously play a synergic role in cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of natural medicine composition, more specifically relate to a kind of natural medicine composition that is made up of andrographis paniculata longan water decoction concentrated extract, andrographolide, Piperlongum ethanol extract and piperine, the natural medicine composition The preparation method and the use of the natural medicine composition in the preparation of medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs, whether used alone or in combination, can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy...

Claims

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Application Information

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IPC IPC(8): A61K36/67A61P1/12A61P35/00A61K36/19A61K31/365A61K31/4525
Inventor 张宗升
Owner 张宗升
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