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Preparation of alginic acid cerium complex and application of alginic acid cerium as antiemetic drugs

A technology of cerium alginate and complex, which is applied to the preparation of cerium alginate complex and its application as an antiemetic drug, can solve the problems of limited application, high toxicity and the like, and achieves good antiemetic effect and obvious antagonism effect.

Inactive Publication Date: 2013-07-31
岳旺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cerium compounds have anti-inflammatory, anti-emetic, antibacterial and other biological activities, but their application is limited due to their high toxicity

Method used

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  • Preparation of alginic acid cerium complex and application of alginic acid cerium as antiemetic drugs
  • Preparation of alginic acid cerium complex and application of alginic acid cerium as antiemetic drugs
  • Preparation of alginic acid cerium complex and application of alginic acid cerium as antiemetic drugs

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Experimental program
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Embodiment approach

[0015] The first step: preparation of cerium alginate complex

[0016] Take a certain amount of cerium sulfate and dissolve it in 25ml 20mmol L -1 Slowly add 5 mg / ml low molecular weight sodium alginate to the HEPES buffer until a small amount of precipitation appears, adjust the pH to 7 with NaOH, centrifuge, and separate the supernatant to obtain the water-soluble cerium alginate complex by vacuum distillation , to light yellow powder, that is, cerium alginate complex.

[0017] Step 2: preparation of preparation

[0018] (1) Preparation of pharmaceutical composition capsule preparation of the present invention

[0019] Take 100 mg of the cerium alginate complex prepared in the above steps, weigh 395 mg of starch and 5 mg of magnesium stearate at the same time, mix evenly, fill capsules, and make capsules with a net weight of 500 mg each.

[0020] (2) preparation of pharmaceutical composition tablet of the present invention

[0021] Take 100 mg of the cerium alginate comp...

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Abstract

The invention relates to an alginic acid cerium complex, a preparation method and an application of the alginic acid cerium complex in preparation of antiemetic drugs, the alginic acid cerium complex is prepared by cerous sulfate and sodium alginate with low molecular weight, and has good curative effect to emesis.

Description

technical field [0001] The present invention relates to the preparation of cerium alginate complex and its application as antiemetic medicine. Background technique [0002] Vomiting is an unbearably painful human response. Improper diet, mental stress, gastrointestinal diseases, cancer radiotherapy and chemotherapy, drug toxicity, postoperative, motion sickness and pregnancy can cause nausea and vomiting. Frequent and severe vomiting can cause malnutrition, dehydration, electrolyte imbalance, etc. Complications, especially vomiting caused by cancer radiotherapy and chemotherapy, are one of the reasons why patients give up treatment. [0003] At present, antiemetic drugs commonly used in clinic mainly include histamine, acetylcholine, dopamine receptor antagonists, bradykinin (NK 1 ) and 5-hydroxytryptamine (5-HT 3 ) receptor antagonists, etc., but these drugs have poor curative effect on vomiting after chemotherapy, and have strong toxic and side effects, which are greatl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04A61K31/715A61P1/08
Inventor 岳旺
Owner 岳旺
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