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Novel use of adefovir dipivoxil or medicinal salt thereof

A technology of tenofovir and dipivoxil, which is applied in the direction of antiviral agents, etc., and can solve problems such as applications that have not been reported

Inactive Publication Date: 2013-08-07
FUJIAN COSUNTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application in other aspects has not been reported

Method used

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  • Novel use of adefovir dipivoxil or medicinal salt thereof
  • Novel use of adefovir dipivoxil or medicinal salt thereof
  • Novel use of adefovir dipivoxil or medicinal salt thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 (tablet)

[0036] prescription:

[0037]

[0038] Wherein, if tenofovir disoproxil medicinal salt is used for feeding, the dosage is based on tenofovir disoproxil.

[0039] Preparation method: Grind the above-mentioned microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate through 100 mesh respectively, dry at 100°C under reduced pressure for more than 10 hours, cool to room temperature, and then mix with tenofovir fumarate The pyrofurate is mixed evenly, granulated by a dry granulator, and compressed into 1000 tablets, to be ready.

Embodiment 2

[0040] Embodiment 2 (injection)

[0041] prescription:

[0042]

[0043] Wherein, if tenofovir disoproxil medicinal salt is used for feeding, the dosage is based on tenofovir disoproxil.

[0044] Preparation method: Dissolve tenofovir disoproxil fumarate in Glycofurol75, then add benzyl alcohol to dissolve, add water to 3ml, then filter the mixture through a sterile microporous filter and seal it in a 3ml ampoule glass vial .

Embodiment 3

[0045] Embodiment 3 (capsules)

[0046] prescription:

[0047]

[0048] Wherein, if tenofovir disoproxil medicinal salt is used for feeding, the dosage is based on tenofovir disoproxil.

[0049] Preparation method: the above-mentioned microcrystalline cellulose and sodium carboxymethyl starch were respectively crushed through 100 meshes, dried under reduced pressure at 100°C for more than 10 hours, cooled to room temperature, and mixed evenly with tenofovir disoproxil fumarate , dry granulation machine granulation, adding magnesium stearate, mixing, filling into 1000 empty capsules to obtain the capsules of the pharmaceutical composition.

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Abstract

The invention relates to novel use of adefovir dipivoxil or a medicinal salt thereof, and particularly relates to application in preparation of a drug for treating influenza A or B, and application in preparation of the drug for preventing the influenza A or B.

Description

technical field [0001] The invention relates to a new application of tenofovir disoproxil or a pharmaceutically acceptable salt thereof, including the application in preventing and treating various influenzas. Background technique [0002] Tenofovir disoproxil fumarate (fovir disoproxil fumarate, TDF), its chemical name: 9-[(R)-2-[[bis[[(isopropoxycarbonyl)oxy]methoxy Base]phosphinyl]methoxy]-propyl]adenine fumarate (1:1), its structure is as follows formula 1: [0003] [0004] Formula 1 [0005] Tenofovir disoproxil fumarate was developed by Glead Scierices of the United States and is a nucleotide reverse transcription inhibitor for the treatment of HIV infection. It is suitable for use in combination with other antiretroviral drugs to treat HIV-1 infection. [0006] In a study of 186 HIV-1-infected patients, patients received placebo or one of three doses of tenofovir disoproxil fumarate (75, 150, or 300 mg), in combination with other Antiretroviral drugs, medicati...

Claims

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Application Information

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IPC IPC(8): A61K31/675A61P31/16
Inventor 李国栋杨喜鸿苏葳姚建堤
Owner FUJIAN COSUNTER PHARMA
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