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Application of traditional Chinese medicine composition in preparing antithrombotic drug

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, medical formula, plant raw material, etc., can solve the problems such as application of undisclosed traditional Chinese medicine composition, and achieve the effect of maintaining normal viscosity, maintaining normal shape, and resisting platelet aggregation.

Active Publication Date: 2013-08-14
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent does not disclose the application of the traditional Chinese medicine composition in the preparation of antithrombotic drugs

Method used

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  • Application of traditional Chinese medicine composition in preparing antithrombotic drug
  • Application of traditional Chinese medicine composition in preparing antithrombotic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] prescription:

[0063] Forsythia 255g Honeysuckle 255g Radix Radix 255g Rhubarb 51g

[0064] Patchouli 85g Mianma Guanzhong 255g Rhodiola 85g Menthol 7.5g

[0065] 85 grams of roasted ephedra, 85 grams of fried bitter almonds, 255 grams of Houttuynia cordata

[0066] Licorice 85g Gypsum 255g.

[0067] Preparation:

[0068] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0069] (2) Patchouli is broken, add 6 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0070] (3) Forsythia, ephedra, Houttuynia cordata, and rhubarb, extracted twice with 8 times the amount of 70% ethanol, the first time for 2 hours, the second time for 1.5 hours, the extracts were combined and filtered, the ethanol was recovered, and the filtrate was used for later use;

[0071] (4) ...

Embodiment 2

[0076] prescription:

[0077] Forsythia 200g Honeysuckle 300g Radix Radix 200g Rhubarb 60g

[0078] Patchouli 60g Mianma Guanzhong 300g Rhodiola 60g Menthol 9g

[0079] 60 grams of roasted ephedra, 100 grams of fried bitter almonds, 200 grams of Houttuynia cordata

[0080] 100 grams of licorice and 200 grams of gypsum.

[0081] Preparation:

[0082] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0083] (2) Patchouli is broken, add 5 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0084] (3) Forsythia, Sun-roasted Ephedra, Houttuynia cordata, and rhubarb were extracted twice with 6 times the amount of 50% ethanol, the first time was 1 hour, and the second time was 2.5 hours, the extracts were combined and filtered, the ethanol was recovered, and the filtrate...

Embodiment 3

[0090] prescription:

[0091] Forsythia 300g Honeysuckle 200g Radix Radix 300g Rhubarb 60g

[0092] Patchouli 100g Mianma Guanzhong 200g Rhodiola 60g Menthol 5g

[0093] 100 grams of roasted ephedra, 60 grams of fried bitter almonds, 300 grams of Houttuynia cordata

[0094] 60 grams of licorice and 300 grams of gypsum.

[0095] Preparation:

[0096] (1) Weigh Chinese herbal medicines according to the above prescription, and select them;

[0097] (2) Patchouli is broken, add 8 times the amount of water to extract the volatile oil, the oil extraction time is 4 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0098] (3) Forsythia, Sun-burned Ephedra, Houttuynia cordata, and rhubarb were extracted twice with 10 times the amount of 90% ethanol, the first time was 3 hours, and the second time was 2.5 hours, the extracts were combined and filtered, the ethanol was recovered, and the filtrat...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparing an antithrombotic drug. The traditional Chinese medicine composition is mainly composed of fructus forsythia, honeysuckle, isatis root, rheum officinale, pogostemon cablin, rhizoma dryopteris crassirhizomae, rhodiola rosea and the like. The traditional Chinese medicine composition has an overall adjustment advantage, can effectively inhibit platelet aggregation and thrombus formation, keeps the normal viscosity of blood and realizes multi-targeting therapeutics. Experiments demonstrate that the traditional Chinese medicine composition has a significant curative effect for platelet aggregation resistance and anticoagulation.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in the preparation of antithrombotic drugs, which belongs to the field of Chinese herbal medicines. Background technique [0002] The incidence of thrombotic diseases is high, and the incidence has increased rapidly in recent years. Thrombotic diseases can be divided into arterial thrombosis and venous thrombosis. Arterial thrombosis is the primary cause of cardiovascular disease morbidity and death. Myocardial infarction is the disease with the highest fatality rate. Cerebral infarction is the disease with the highest disability rate. Venous thrombosis Pulmonary embolism is also one of the causes of sudden death. The formation of thrombus is difficult to monitor, the recurrence rate is high, and the disability rate is high. For thrombotic diseases, preventive treatment is very important. [0003] The initial cause of arterial thromboembolism is arterial damage or ...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P7/02A61K33/06
Inventor 贾振华魏聪王永
Owner BEIJING YILING PHARMA