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Preparation method of monodisperse multicomponent multiple emulsion

A multiple emulsion, monodisperse technology, applied in chemical instruments and methods, chemical/physical/physicochemical processes, chemical/physical processes, etc., can solve problems such as difficulty in preparing multi-component emulsions, poor stability, and needs

Active Publication Date: 2013-08-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can prepare multiple emulsions in large quantities. The dispersed phase of the prepared multiple emulsions is better than that prepared by the overall multi-step emulsification method, but it still cannot accurately control the internal structure of the multiple emulsions, such as the number of droplets contained, etc.
(3) Microfluidic technology emulsification method, which uses multi-phase fluids to perform multiple shear emulsification in microchannels to form multiple emulsions. This method can precisely control the size and structure of multiple emulsions, and the prepared multiple emulsions have good monodispersity properties, but it is difficult to prepare a multi-component emulsion with an ultra-thin wall structure, and this method requires multiple shear emulsification in the microchannel, which has poor stability

Method used

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  • Preparation method of monodisperse multicomponent multiple emulsion
  • Preparation method of monodisperse multicomponent multiple emulsion
  • Preparation method of monodisperse multicomponent multiple emulsion

Examples

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Embodiment 1

[0082] In this example, a monodisperse multi-component water-in-oil-in-oil (W / O / O) emulsion is prepared by the method of the present invention, and the process steps are as follows:

[0083] (1) Preparation of dispersed phase and continuous phase fluid

[0084] Preparation of the first dispersed phase fluid: Add sodium dodecyl sulfate (SDS) into deionized water at normal pressure and room temperature and stir to form the first dispersed phase fluid, the mass ratio of the SDS to deionized water is 0.01: 1;

[0085] Preparation of the second dispersed phase fluid: Add glyceryl ricinoleate (PGPR 90) into medical soybean oil at normal pressure and room temperature and stir evenly to form the second dispersed phase fluid. The amount of PGPR 90 is 0.005 g in soybean oil;

[0086] Preparation of continuous phase fluid: Add Dow Corning 749 (DC749) into simethicone oil at normal pressure and room temperature and stir evenly to form a continuous phase fluid. The mass ratio of DC749 to...

Embodiment approach 1

[0090] Embodiment 1: When the flow rate Q of the first dispersed phase fluid B = 200 μL / h, the flow rate Q of the second dispersed phase fluid A1 = 20 μL / h, the flow rate Q of the continuous phase fluid in the first single-stage droplet generator C1 = 40 μL / h, flow Q in the second single-stage droplet generator C2 = 300 μL / h, the oil-in-oil emulsion droplet and the water-in-oil emulsion droplet meet the contact of each oil-in-oil emulsion droplet with a water-in-oil emulsion droplet in the enlarged chamber of the collecting tube 20, The oil-in-oil emulsion droplets spread to the water-in-oil emulsion droplets to form monodisperse multi-component W / O / O emulsion droplets (see Figure 10 );

Embodiment approach 2

[0091] Embodiment 2: When the flow rate Q of the first dispersed phase fluid B = 150 μL / h, the flow rate Q of the second dispersed phase fluid A1 = 80 μL / h, the flow rate Q of the continuous phase fluid in the first single-stage droplet generator C1 = 70 μL / h, flow Q in the second single-stage droplet generator C2 = 300 μL / h, the oil-in-oil emulsion droplet and the water-in-oil emulsion droplet enter the enlarged chamber of the collecting tube 20 to meet the contact of each oil-in-oil emulsion droplet with a water-in-oil emulsion droplet, The oil-in-oil emulsion droplets spread to the water-in-oil emulsion droplets to form monodisperse multi-component W / O / O emulsion droplets (see Figure 11 );

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Abstract

The invention relates to a preparation method of monodisperse multicomponent multiple emulsion. The preparation method comprises the steps as follows: (1) preparing a disperse phase fluid and a continuous phase fluid; (2) preparing monodisperse multicomponent multiple emulsion droplets by the following steps: filling the fluids prepared in the step (1) into different droplet generators of a microfluid device to form emulsion droplets, wherein the emulsion droplets formed in the different droplet generators are contacted in an expanded cavity and the emulsion droplets formed in one droplet generator are spread on the emulsion droplets formed in another droplet generator to form the multiple emulsion droplets; and (3) collecting the monodisperse multicomponent multiple emulsion.

Description

technical field [0001] The invention belongs to the field of preparation of monodisperse multiple emulsions, in particular to a method for preparing monodisperse multi-component multiple emulsions by using microfluidic technology. Background technique [0002] Multiple Emulsions, also known as Emulsions of Emulsions, is a combination of oil-in-water (O / W) and water-in-oil (Water-in-Oil, W / O) type emulsion further emulsifies the complex emulsion formed in another continuous phase. Oil droplets containing water droplets are suspended and dispersed in the water phase to form emulsions called water-in-oil-in-water (W / O / W) type double emulsions, and water droplets containing oil droplets are suspended in oil phases to form emulsions It is an oil-in-water-in-oil (O / W / O) type double emulsion, which is a three-phase system. The W / O / W type emulsion is redispersed into oil to form a water-in-oil-in-oil (W / O / W / O) type triple emulsion, and the O / W / O type emulsion is redispersed to wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
Inventor 邓楠楠褚良银汪伟巨晓洁谢锐D·A·威茨
Owner SICHUAN UNIV