Mold for preparing accellular small intestine submucosa matrix material

A technology for the submucosa and matrix material of the small intestine, applied in the field of medical biomaterials, can solve the problems of affecting the porosity of the material and destroying the three-dimensional structure, and achieve the effect of ensuring the porosity

Active Publication Date: 2015-04-08
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cook Biotech Incorporated adopts the vacuum pressing method, which will compress the spatial structure of the SIS matrix material, destroy the natural ECM three-dimensional structure, and affect the porosity of the material

Method used

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  • Mold for preparing accellular small intestine submucosa matrix material
  • Mold for preparing accellular small intestine submucosa matrix material
  • Mold for preparing accellular small intestine submucosa matrix material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The mold used for preparing the matrix material of the decellularized small intestine submucosa in this example consists of two parts: a negative sheet and a pressing net. Described bottom film is the square plate that pin is provided with on four sides, and described pin is perpendicular to square plate, as figure 1 shown. The press net is a square frame with a square frame structure or a mesh structure inside, and the four side lengths of the press net are all 1-3 cm shorter than the negative film. The unit shapes of the network structure include square, rhombus and circle. The frame structure pressing net is as figure 2 As shown, the mesh structure pressing net is as image 3 shown (shown as a rhombus). The height of the needles is 0.5-1.5 cm, the diameter is 0.5-2.0 mm, and the distance between the needles is 0.5-2 cm. There is welding between the needle and the square plate. The negative, the needle on the negative, and the pressing net are all made of 316L ...

Embodiment 2

[0022] The porosity of the decellularized porcine small intestinal submucosa matrix material prepared by using the mold provided in Example 1 was measured by mercury intrusion porosimetry, and compared with the product of Biodesign Surgisis. Results: The porosity of the acellular porcine small intestinal submucosa matrix material prepared by the mold provided in Example 1 was 87.8±2.51, and the porosity of the Biodesign Surgisis product was 78.3±6.38.

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Abstract

The invention provides a mold for preparing an accellular small intestine submucosa matrix material, which is composed of a base and a pressure screen, wherein the base is a square plate with pins on four sides, and the pins are perpendicular to the square plate; the pressure screen is a square frame with a square frame structure or reticular structure inside; and the length of the four sides of the pressure screen is 1-3 cm smaller than that of the base. When being used for preparing the accellular porcine small intestine submucosa matrix material, the mold can not compress the space structure of the accellular porcine small intestine submucosa matrix material or destroy the three-dimensional structure of the natural extracellular matrix, and can ensure the porosity of the prepared accellular porcine small intestine submucosa matrix material.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a mold for preparing decellularized small intestine submucosa matrix material. Background technique [0002] Animal tissue-based extracellular matrix (ECM) materials based on the principles of tissue engineering are the main development direction in the field of medical implant materials. The acellular small intestinal submucosa (SIS) matrix material is an ideal soft tissue repair material. The advantages of acellular small intestinal submucosa matrix materials include: 1) low immunogenicity and high histocompatibility; 2) the unique structure and composition have a biological basis for actively inducing the regeneration of various tissues; 3) a wide range of applications, can It is suitable for the repair of various soft tissues in the body; 4) It has antimicrobial activity. Acellular small intestinal submucosa matrix materials have been clinically applied with a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/56A61L31/00A61L31/14
Inventor 赵博王振军
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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